Table 1. Reduced growth of Ts65Dn cerebellum during postnatal development.
| Age | Normalized cerebellar area, % | EGL thickness, % | IGL thickness, % | GC density, % |
|---|---|---|---|---|
| P0 | 96.7 | 93.9 | NA | NA |
| P6 | 73.1** | 76.9** | NA | 82* |
| P14 | 79.8** | NA | 85.2** | 87.4* |
| P24 | 85.2* | NA | 85.1** | 91** |
| P28 | 94.8 | NA | 85.0* | 92* |
| P35 | 86.0* | NA | 76.5* | 94 |
| Adult | 81.7* | NA | 86.8* | 76** |
Ts65Dn values are expressed as percentage of euploid. n = 10 for each genotype at each time point for P0, P6, P14, and Adult. At P24, Euploid, n = 6, Ts65Dn, n = 6. At P28 and P35, Euploid, n = 7, Ts65Dn, n = 7. NA, not applicable. *, Statistically significant by Student's test, P ≤ 0.05; **, statistically significant by Student's t test, P ≤ 0.001. Adult data are from Baxter et al. (18).