TABLE 1.
Expt. no. | Parameter | Phosphorimager results
|
Residual decay resultsc
|
|||
---|---|---|---|---|---|---|
t1/2 (h) | 95% CI | Pb | t1/2 (h) | 95% CI | ||
1d | Cells−1a | 33.97 | 30.00-39.16 | |||
2-LTR circles | 35.40 | 32.15-39.37 | 0.510 | NA | NA - 367.45 | |
Total HIV | 49.45 | 41.01-62.26 | 0.005 | |||
2d | Cells−1 | 29.90 | 23.63-40.71 | |||
2-LTR circles | 26.12 | 24.31-28.22 | 0.025 | 206.53 | 1225.37 - 112.77 | |
1-LTR circles | 27.50 | 22.11-36.38 | 0.590 | 342.69 | NA - 64.66 | |
3e | Cells−1 | 27.74 | 25.66-30.19 | |||
2-LTR circles | 28.30 | 26.13-30.85 | 0.691 | NA | NA - 291.47 | |
1-LTR circles | 23.88 | 20.56-28.48 | 0.185 | 171.46 | NA - 64.99 | |
Total HIV | 21.02 | 18.07-25.13 | 0.042 |
Cells−1, doubling time of the cells.
P values are for comparison of t1/2 and cells−1.
Residual decay relative to cell division. NA, not available.
Experiment with replication-competent virus.
Experiment with integrase mutant virus.