Table 1.

Pathways involved in the HIV-VLPs-activated MDDCs. The pathways are derived from the BioCarta through the Cancer Genome Anatomy Project at http://cgap.nci.nih.gov/Pathways/BioCarta_Pathways. Genes with at least a 2-fold modulation (up or downregulation) have been taken into consideration. Upregulated genes in bold and underline; Downregulated genes in plain text.

Pathways	HIV-VLP vs PBS	HIV-VLP vs LPS	Pathways	HIV-VLP vs PBS	HIV-VLP vs LPS	Pathways	HIV-VLP vs PBS	HIV-VLP vs LPS
Cell cycle, death			Transcription			Immunology/Signaling
Cadmium induces DNA synthesis and proliferation in macrophages	NFKB1 MAPK1	TNF	Acetylation and Deacetylation of RelA in The Nucleus	NFKB1 FADD	NFKBIA TNF FADD	AKT Signaling Pathway	FOXO3A NFKB1 CASP9 YWHAH
Caspase Cascade in Apoptosis	BIRC3 CASP7 CASP2 CASP9 PARP1		Activation of PKC through G protein coupled receptor	GNAQ NFKB1		B Lymphocyte Cell Surface Molecules	CD40 FCGR2A ICAM1 LTBR ITGAL PTPRC	NFKBIA
Free Radical Induced Apoptosis	GSR IL8 NFKB1		Chaperones modulate interferon Signaling Pathway	DNAJA3 IFNG NFKB1	IFNG LIN7A NFKBIA RB1 TNF	CD40L Signaling Pathway	CD40 DUSP1 TNFAIP3 TRAF6 IKBKB	DUSP1 MAP3K1 NFKBIA TNFAIP3
Induction of apoptosis through DR3 and DR4/5 Death Receptors	BID CASP10 CASP7 TRAF2 CASP9 FADD		Double Stranded RNA Induced Gene Expression	NFKB1		CTL mediated immune response against target cells	ICAM1 B2M LTBR ITGAL
Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells	GNAQ NFKB1 PRKAR1B CAMK1		Human Cytomegalovirus and Map Kinase Pathways	MAP2K3 NFKB1 MAP2K6 MAPK1		fMLP induced chemokine gene expression in HMC-1 cells	FPR1 MAP2K2 NFKB1 CAMK1 MAP2K6 MAPK1
Regulation of BAD phosphorylation	BCL2L1 IGF1R PRKAR1B MAPK1 RPS6KA1 YWHAH		NFkB activation by Nontypeable Hemophilus influenzae	DUSP1 EP300 MAP2K3 NFKB1 NR3C1 SMAD4 MAP2K6 SMAD3 TGFBR2	DUSP1 IL8 NFKBIA SMAD4 TNF IKBKB MAP2K6 SMAD3	Monocyte and its Surface Molecules	ICAM1 ICAM2 CD44 LTBR SELE CD83 HLA-DOA ITGAL PECAM1
Role of Mitochondria in Apoptotic Signaling	BCL2L1 BID BIRC3 CASP7 ENDOG CASP9 PDCD8		NF-kB Signaling Pathway	IRAK1 NFKB1 TNFAIP3 TRAF6 FADD	IL1A MAP3K1 NFKBIA TNF TNFAIP3 FADD	T Cytotoxic Cell Surface Molecules	CD8A ICAM1 LTBR CD2 ITGAL PTPRC
SODD/TNFR1 Signaling Pathway	BIRC3 TRAF2 FADD		Signal transduction through IL1R	IL1B MAP2K3 NFKB1 TRAF6 IL1RAP MAP2K6	IL1A MAP3K1 NFKBIA TNF IL1RAP MAP2K6	T Helper Cell Surface Molecules	ICAM1 LTBR CD2 CD4 ITGAL PTPRC
Stress Induction of HSP Regulation	CASP9 MAPKAPK3	IL1A TNF CASP9 CYC1	TNFR1 Signaling Pathway	PAK2 TRAF2 CASP2 FADD PARP1		The 4-1BB-dependent immune response	IFNG NFKB1 TNFSF9 TRAF2
TNF/Stress Related Signaling	MAP2K3 NFKB1 TANK TRAF2 CASP2 MAP2K6		TNFR2 Signaling Pathway	DUSP1 NFKB1 TANK TNFAIP3 TRAF2	DUSP1 MAP3K1 NFKBIA TANK TNFAIP3 TNFRSF1B	Toll-Like Receptor Pathway	IRAK1 MAP2K3 MAP3K7IP2 NFKB1 TRAF6 MAP2K
Pathways	HIV-VLP vs PBS	HIV-VLP vs LPS	Pathways	HIV-VLP vs PBS	HIV-VLP vs LPS
Cytokine Network			Phagocytosis
Cells and Molecules involved in local acute inflammatory response	ICAM1 IL8 LTBR CERKL ITGAL		Instracellular protein transport	APG9L1 RERE RNF4
Cytokine Network	IFNG IL18 IL8		Cytoskeleton
Cytokines and Inflammatory Response	CSF1 CSF2 IFNG IL7 IL8 IL15 IL15RA IL23 PTGS2 CD4		Cellular motiliyshape	ARHGEF2 ARPC2 C14orf43 FLJ39378 MARCKS PDE4B PDE5A PLEK PPP1R15A PPP1R15B SLC11A2 SLC1A3 SLC20A1 SLC43A3
IL 17 Signaling Pathway	CD8A IL8 CD58 CD2 CD4
Th1/Th2 Differentiation	IL18 IL18R