Table 2.
Functional categories of genes differentially upregulated in HIV-VLPs-induced MDDCs. (+) 1.5-fold upregulation; (++) 2–5-fold upregulation; (+++) >5-fold upregulation.
| Pathway | HIV-VLP vs PBS | HIV-VLP vs LPS | Pathway | HIV-VLP vs PBS | HIV-VLP vs LPS |
| Cell cycle, death | Chemokine/Immunology | ||||
| TNF | ++ | + | Innate response | ||
| BIRC3 | ++ | IL8 | +++ | ++ | |
| CASP7 | + | CXCL1 | ++ | ++ | |
| BID | ++ | IL1a | ++ | ++ | |
| PAK2 | ++ | IL1b | ++ | ||
| TRAF2 | ++ | IL6 | ++ | ||
| BCL2L1 | + | CCL4 | ++ | ||
| IGF1R | ++ | IFNG | + | ||
| TNFAIP3 | ++ | PTGER4 | |||
| TANK | ++ | Adaptive response | |||
| PSEN1 | + | EBI2 | ++ | ||
| TNFRSF1B | +++ | + | ICAM1 | ++ | |
| Transcription | B2M | + | |||
| NFKB1 | + | Receptors | |||
| NFKBIA | ++ | IL15RA | ++ | ||
| IRAK1 | + | IL18R1 | ++ | ||
| MAP3K1 | + | IL23A | ++ | ||
| JUNB | + | IL2RB | ++ | ||
| Signaling | FCGR2A | ++ | |||
| MAP2K7IP2 | + | IL7R | ++ | ||
| DUSP1 | ++ | + | CD83 | ++ | |
| MAP2K3 | + | Growth Factors | |||
| PAK2 | ++ | CSF1 | ++ | ||
| RB1 | + | CSF2 | + | ||
| FOXO3A | + | Migration and Homeostasis | |||
| FYN | + | CCR7 | + | ||
| GNAQ | + | FPR1 | ++ | ||
| MEF2A | + | SELE | ++ | ||
| RAPGEF2 | + | CD44 | ++ | ||
| LTBR | + | ||||
| T-cell activation/polarization | |||||
| CD40 | ++ | ||||
| TNFSF9 | + | ||||
| IL18 | + | ||||