Figure 1.

Scatter plots of gene expression profiles. (a) A scatter plot of the expression profiles for 2 genes (with 6 components) with standard errors indicated, (b) A scatter plot of the expression profiles for 2 genes (with 6 components) identical to the expression profiles in (a), but with higher standard errors. The gene pairs in (a) and (b) have identical Euclidean distances, identical correlation coefficients, and identical error-weighted similarity. However, in the CORE clustering algorithm, genes whose expression measurements have higher error (g₃ or g₄) provide less information about which cluster the gene belongs to, and the gene makes less of a contribution toward the calculation of clustering parameters.