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. 2026 Sep 17;27(18):8294. doi: 10.3390/ijms27188294
ABAD Amyloid-binding alcohol dehydrogenase
ACSL4 Acyl-CoA synthetase long-chain family member 4
AD Alzheimer’s disease
AHEAD 3–45 Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Disease (clinical trial)
ANLS Astrocyte-Neuron Lactate Shuttle
APOE Apolipoprotein E
APOE4 Apolipoprotein E ε4 allele/gene
APP Amyloid precursor protein
ARE Antioxidant response element
ATP Adenosine triphosphate
ATP7A/ATP7B Copper-transporting P-type ATPases A/B
Aβ Amyloid-beta
BACE1 Beta-site Amyloid Precursor Protein Cleaving Enzyme 1
CDK5 Cyclin-dependent kinase 5
CoQ10 Coenzyme Q10
CTR1 Copper transporter 1
CSF Cerebrospinal fluid
DAM Disease-associated microglia
DAMPs Damage-associated molecular patterns
DHODH Dihydroorotate dehydrogenase
DMT1 Divalent metal transporter 1
ELAD ‘Evaluating Liraglutide in Alzheimer’s Disease’ (clinical trial)
EVOKE/EVOKE+ Phase 3 clinical trials of oral semaglutide in early symptomatic Alzheimer’s disease
FDG-PET Fluorodeoxyglucose positron emission tomography
FSP1 Ferroptosis suppressor protein 1
GLP-1 Glucagon-like peptide-1
GLUT1 Glucose transporter 1
GLUT3 Glucose transporter 3
GPX4 Glutathione peroxidase 4
GSDMD Gasdermin D
GSH Glutathione
GSK3β Glycogen synthase kinase-3β
HDAC(s) Histone deacetylase(s)
HETEs Hydroxyeicosatetraenoic acids
IL-18 Interleukin-18
IL-1β Interleukin-1β
KEAP1 Kelch-like ECH-associated protein 1
LIP Labile iron pool
LPCAT3 Lysophosphatidylcholine acyltransferase 3
LPS Lipopolysaccharide
LTP Long-term potentiation
MCT1/2/4 Monocarboxylate transporter 1/2/4
MLKL Mixed lineage kinase domain-like protein
NAD+ Nicotinamide adenine dinucleotide (oxidised form)
NADPH Nicotinamide adenine dinucleotide phosphate (reduced form)
NCOA4 Nuclear receptor coactivator 4
NLRP3 NOD-, LRR- and pyrin domain-containing protein 3
NMDA N-methyl-D-aspartate
NO Nitric oxide
NRF2 Nuclear factor erythroid 2-related factor 2
oxPEs Oxidised phosphatidylethanolamines
OXPHOS Oxidative phosphorylation
oxPUFAs Oxidised polyunsaturated fatty acids
p-tau217 Phosphorylated tau at threonine 217 (blood biomarker)
PANoptosis Combined apoptosis, pyroptosis, and necroptosis cell death pathway
PI3K/Akt Phosphoinositide 3-kinase/protein kinase B signalling pathway
QSM Quantitative susceptibility mapping
RCD Regulated cell death
RIPK1/3 Receptor-interacting protein kinase 1/3
RNS Reactive nitrogen species
ROS Reactive oxygen species
SCFAs Short-chain fatty acids
SS-31 Elamipretide (mitochondria-targeted, cardiolipin-stabilising peptide)
TCA Tricarboxylic acid
TfR1 Transferrin receptor 1
TLR4 Toll-like receptor 4
TNF-α Tumour necrosis factor-α
TPP+ Triphenylphosphonium cation
ZIP Zrt/Irt-like protein (zinc transporter, SLC39 family)
ZnT Zinc transporter (SLC30 family)
β-HB Beta-hydroxybutyrate