TABLE 3.

Partial correlations of changes from baseline to year 1, adjusted for baseline age, sex, and race/ethnicity

	Weight	Proinsulin	1/FI	ISI	CIR	IGR	Fasting glucose	A1C
Placebo (n = 933)
Weight	1
Fasting proinsulin	0.36	1
1/FI	−0.30	−0.39	1
ISI	−0.33	−0.41	0.98	1
CIR	−0.02	0.02	−0.14	−0.08	1
IGR	0.01	0.03	−0.07	−0.06	0.89	1
Fasting glucose	0.30	0.32	−0.34	−0.49	−0.28	−0.05	1
A1C	0.22	0.19	−0.11	−0.13	−0.07	−0.02	0.22	1
Metformin (n = 937)
Weight	1
Fasting proinsulin	0.33	1
1/FI	−0.29	−0.34	1
ISI	−0.31	−0.35	0.98	1
CIR	0.00	0.03	−0.22	−0.17	1
IGR	0.02	0.05	−0.16	−0.15	0.89	1
Fasting glucose	0.26	0.31	−0.34	−0.46	−0.24	−0.06	1
A1C	0.26	0.24	−0.16	−0.18	0.00	0.04	0.20	1
Lifestyle (n = 946)
Weight	1
Fasting proinsulin	0.37	1
1/FI	−0.38	−0.38	1
ISI	−0.40	−0.37	0.98	1
CIR	−0.07	0.03	−0.15	−0.10	1
IGR	−0.02	0.03	−0.12	−0.10	0.89	1
Fasting glucose	0.34	0.31	−0.41	−0.53	−0.26	−0.06	1
A1C	0.35	0.29	−0.23	−0.24	−0.08	−0.04	0.25	1

Correlations with an absolute value >0.07 (placebo), >0.06 (metformin), and >0.06 (lifestyle) are significant at the 0.05 level, and correlations are adjusted for age, sex, and race/ethnicity. 1/FI, 1/fasting insulin.