FIG. 3.

HSV-specific antibody titers in serum of therapeutically vaccinated mice. Four months after primary corneal infection, mice with latent ocular HSV infections were vaccinated with HSV-1 mutants or control vaccine. Two weeks after vaccination, HSV-specific antibody levels in serum were determined by (A) ELISA and (B) virus neutralization assay. Results are shown for one of two experiments with similar results and reported as mean log titer ± SEM for ELISA (n = 12) and virus neutralization (n = 4 to 6). ∗, P < 0.001 to 0.003 compared to control vaccine.