53BP1	p53-binding protein 1
AAV	adeno-associated virus
acetyl-CoA	acetyl coenzyme A
AKT	AKT serine/threonine kinase (protein kinase B)
AMPK	AMP-activated protein kinase
ATF4	activating transcription factor 4
ATG	autophagy-related protein/gene
ATG5/ATG12/ATG16L1	autophagy-related proteins 5, 12, and 16-like 1
ATM	ataxia-telangiectasia mutated kinase
ATP	adenosine triphosphate
ATR	ataxia-telangiectasia and Rad3-related kinase
BCL-2/BCL2	B-cell lymphoma 2
BECN1	beclin 1
C/EBPβ	CCAAT/enhancer-binding protein beta
CANTOS	Canakinumab Anti-inflammatory Thrombosis Outcomes Study
CCL	C-C motif chemokine ligand
cFLIP	cellular FLICE-like inhibitory protein
cGAS	cyclic GMP-AMP synthase
CHK1/CHK2	checkpoint kinases 1 and 2
CXCL	C-X-C motif chemokine ligand
D+Q	dasatinib plus quercetin
DDR	DNA damage response
DNA	deoxyribonucleic acid
DNMT	DNA methyltransferase
DR5	death receptor 5
ECM	extracellular matrix
eIF2α	eukaryotic translation initiation factor 2 alpha
EV	extracellular vesicle
FLICE	FADD-like interleukin-1β-converting enzyme
FMT	fecal microbiota transplantation
FOXO	forkhead box O transcription factor
GABARAP	GABA type A receptor-associated protein
γH2AX	phosphorylated histone H2AX
H3K9me3	histone H3 lysine 9 trimethylation
HMGB1	high-mobility group box 1
HOPS	homotypic fusion and protein sorting complex
HSP90	heat shock protein 90
IGF-1	insulin-like growth factor 1
IIS	insulin/IGF-1 signaling
IL	interleukin
IL-1R	interleukin-1 receptor
IRAK1	interleukin-1 receptor-associated kinase 1
JAK	Janus kinase
KLF4	Krüppel-like factor 4
LC3	microtubule-associated protein 1 light chain 3
LC3-II	lipidated form of LC3
LPS	lipopolysaccharide
MAPK	mitogen-activated protein kinase
mRNA	messenger RNA
mtDNA	mitochondrial DNA
mTOR	mechanistic target of rapamycin
mTORC1	mechanistic target of rapamycin complex 1
MYC	MYC proto-oncogene transcription factor
NAD+	oxidized nicotinamide adenine dinucleotide
NF-κB	nuclear factor kappa B
NLRP3	NLR family pyrin domain-containing 3
OCT4	octamer-binding transcription factor 4
OGG1	8-oxoguanine DNA glycosylase 1
OSK	OCT4, SOX2, and KLF4
p16INK4a	cyclin-dependent kinase inhibitor 2A isoform p16INK4a
p21/p21CIP1	cyclin-dependent kinase inhibitor 1A
p38 MAPK	p38 mitogen-activated protein kinase
p53	tumor protein p53
p62/SQSTM1	sequestosome 1
PARP	poly(ADP-ribose) polymerase
PI3K	phosphoinositide 3-kinase
PINK1	PTEN-induced kinase 1
RB	retinoblastoma protein
RNA	ribonucleic acid
ROS	reactive oxygen species
SA-β-gal	senescence-associated beta-galactosidase
SASP	senescence-associated secretory phenotype
SCFA	short-chain fatty acid
SES	socioeconomic status
SNARE	soluble NSF attachment protein receptor
SOX2	SRY-box transcription factor 2
SRC	SRC family tyrosine kinase
STAT	signal transducer and activator of transcription
STING	stimulator of interferon genes
TERT	telomerase reverse transcriptase
TET	ten-eleven translocation dioxygenase
TFEB	transcription factor EB
TGF-β	transforming growth factor beta
TH10785	experimental small-molecule OGG1 activator
TH5487	experimental small-molecule OGG1 inhibitor
TNF	tumor necrosis factor
TORC1	target of rapamycin complex 1
ULK1	Unc-51-like autophagy activating kinase 1
UV	ultraviolet
VPS34	vacuolar protein sorting 34
WNT	WNT signaling pathway
YAP-TAZ	Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ)