A-fiber	Myelinated sensory fiber
BBB	Blood–brain barrier
C-fiber	Unmyelinated nociceptive fiber
CFA	Complete Freund’s adjuvant
CIP	Congenital insensitivity to pain
cLTMR	C-low-threshold mechanoreceptor
CNS	Central nervous system
COX	Cyclooxygenase
DRG	Dorsal root ganglion
ECG	Electrocardiogram
FDA	U.S. Food and Drug Administration
F	Bioavailability
HEK293	Human embryonic kidney 293 cells
IEM	Inherited erythromelalgia
NaV	Voltage-gated sodium channel
NMDA	N-methyl-D-aspartate receptor
NSAID	Non-steroidal anti-inflammatory drug
PAR-2	Protease-activated receptor 2
PD	Pharmacodynamics
PEPD	Paroxysmal extreme pain disorder
PK	Pharmacokinetics
PN1	Alternative name for Nav1.7
SCN	Sodium channel gene family prefix
SFN	Small-fiber neuropathy
SPID48	Time-weighted sum of pain intensity difference over 48 h
TCAs	Tricyclic antidepressants
TRP	Transient receptor potential channels
TRPV1	Transient receptor potential vanilloid 1
TTX	Tetrodotoxin
TTX-R	Tetrodotoxin-resistant sodium channels
TTX-S	Tetrodotoxin-sensitive sodium channels
VAS	Visual analogue scale
VGSC	Voltage-gated sodium channel
WNT	Wnt signaling pathway