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SAHBA triggers apoptosis in Jurkat cells and inhibits a panel of human leukemia cells. FACS analysis of annexin V-treated cells was used to monitor apoptosis of Jurkat cells treated with 0.5 to 5 μM concentrations of BID BH3 peptide, SAHBA, or SAHBA(G→E) for 20 hours (A). Jurkat, REH, MV4;11, SEMK2, and RS4;11 leukemia cells were treated with serial dilutions of SAHBA (B), BID BH3 peptide (C), or SAHBA(G→E) (D), and MTT assays were performed at 48 hours to measure viability.
