| A |
Area |
| API |
Active pharmaceutical ingredient |
| AR |
Aspect ratio |
| b0
|
Constant term of the polynomial model |
| b1, b2
|
Linear regression coefficients of x1 (pellet composition) and x2 (osmolarity) |
| b11, b22
|
Quadratic regression coefficients of x1 (pellet composition) and x2 (osmolarity) |
| b12
|
Interaction coefficient |
| C |
Circularity |
| d |
Diameter |
| deq
|
Area-equivalent spherical diameter |
| ERL |
Eudragit® RL30D |
| ERS |
Eudragit® RS30D |
| F |
Force (maximum) |
| FeSSGF |
Fed-state simulated gastric fluid |
| GPM |
Glucopyranosyl mannitol |
| GPS |
Glucopyranosyl sorbitol |
| MCC |
Microcrystalline cellulose |
| mOsm |
Milliosmole |
| Mt
|
The percentage of drug dissolved at time t
|
|
Maximum release |
| n |
Number of replicates |
| NSAID |
Non-steroidal anti-inflammatory drug |
| p |
Probability value |
| P |
Perimeter |
| r |
Correlation coefficient |
| R |
Roundness |
| SD |
Standard deviation |
| SEM |
Scanning electron microscope |
| t |
Time |
| t0
|
lag time |
| TEC |
Triethyl citrate |
| τd (h) |
Time when 63.2% of the drug is dissolved |
| UV |
Ultraviolet |
| x1
|
Coded value of the pellet excipient composition |
| x2
|
Coded value of the glucose concentration of the dissolution medium |
| y |
Response variable of the polynomial model |
| β |
Shape factor of the Weibull function |
| σf
|
Surface tensile strength |