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. 2026 Aug 23;18(9):1046. doi: 10.3390/pharmaceutics18091046
A Area
API Active pharmaceutical ingredient
AR Aspect ratio
b0 Constant term of the polynomial model
b1, b2 Linear regression coefficients of x1 (pellet composition) and x2 (osmolarity)
b11, b22 Quadratic regression coefficients of x1 (pellet composition) and x2 (osmolarity)
b12 Interaction coefficient
C Circularity
d Diameter
deq Area-equivalent spherical diameter
ERL Eudragit® RL30D
ERS Eudragit® RS30D
F Force (maximum)
FeSSGF Fed-state simulated gastric fluid
GPM Glucopyranosyl mannitol
GPS Glucopyranosyl sorbitol
MCC Microcrystalline cellulose
mOsm Milliosmole
Mt The percentage of drug dissolved at time t
M∞ Maximum release
n Number of replicates
NSAID Non-steroidal anti-inflammatory drug
p Probability value
P Perimeter
r Correlation coefficient
R Roundness
SD Standard deviation
SEM Scanning electron microscope
t Time
t0 lag time
TEC Triethyl citrate
τd (h) Time when 63.2% of the drug is dissolved
UV Ultraviolet
x1 Coded value of the pellet excipient composition
x2 Coded value of the glucose concentration of the dissolution medium
y Response variable of the polynomial model
β Shape factor of the Weibull function
σf Surface tensile strength