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. 2026 Sep 16;19(9):1464. doi: 10.3390/ph19091464
aa Amino acids
ADME Absorption, distribution, metabolism and excretion
AMED Japan Agency for Medical Research and Development
ATP Adenosine triphosphate
BCDIN3D BCDIN3 domain-containing RNA methyltransferase
BbCDPK4 Babesia bovis calcium-dependent protein kinase 4
BbHT1 Babesia bovis hexose transporter 1
BKI Bumped kinase inhibitor
CCK-8 Cell Counting Kit-8
CC50 50% cytotoxic concentration
CDPK Calcium-dependent protein kinase
CI Combination index
CLogP Calculated logarithm of the octanol/water partition coefficient
CNN Convolutional neural network
CV Coefficient of variation
CYP Cytochrome P450
CYP1A2 Cytochrome P450 1A2
CYP3A4 Cytochrome P450 3A4
DA Diminazene aceturate
DDI Drug Discovery Initiative
DFG Aspartate–phenylalanine–glycine
DNA Deoxyribonucleic acid
ED50 50% effective dose
EDTA Ethylenediaminetetraacetic acid
EGFR Epidermal growth factor receptor
ELQ Endochin-like quinolone
ERBB2 Erb-b2 receptor tyrosine kinase 2
ETKDG Experimental-Torsion Knowledge Distance Geometry
Fa Fraction affected
GI Gastrointestinal
GLUT1 Glucose transporter 1
HTS High-throughput screening
IC50 50% inhibitory concentration
IMDP Imidocarb dipropionate
JSPS Japan Society for the Promotion of Science
KAKENHI Grants-in-Aid for Scientific Research
MDBK Madin–Darby bovine kidney
MMFF94 Merck Molecular Force Field 94
MMV Medicines for Malaria Venture
MTOR Mechanistic target of rapamycin
PAE Predicted aligned error
PAINS Pan-assay interference compounds
PDB Protein Data Bank
PfCDPK4 Plasmodium falciparum calcium-dependent protein kinase 4
PIK3CA Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
PIP4K2A Phosphatidylinositol-5-phosphate 4-kinase type 2 alpha
PLIP Protein–Ligand Interaction Profiler
pLDDT Predicted Local Distance Difference Test
R2 Coefficient of determination
RBC Red blood cell
RefSeq Reference Sequence
RMSD Root-mean-square deviation
ROP18 Rhoptry protein 18
RPS6KB1 Ribosomal protein S6 kinase B1
S/B Signal-to-background ratio
SD Standard deviation
SI Selectivity index
SLC2 Solute carrier family 2
SLC2A1 Solute carrier family 2 member 1
SLC2A2 Solute carrier family 2 member 2
SLC2A3 Solute carrier family 2 member 3
SMILES Simplified molecular-input line-entry system
TPSA Topological polar surface area
Tris-HCl Tris(hydroxymethyl)aminomethane hydrochloride
WISE World-leading Innovative and Smart Education