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. 2026 Sep 21;19(9):1497. doi: 10.3390/ph19091497
AGEs Advanced glycation end products
AKT Protein kinase B
ALT Alanine aminotransferase
ARRIVE Animal Research: Reporting of In Vivo Experiments
AST Aspartate aminotransferase
BrdU 5-bromo-2′-deoxyuridine
BUN Blood urea nitrogen
CD Cluster of differentiation
CI Confidence interval
CMC Carboxymethyl cellulose
DAG Diacylglycerol
DNA Deoxyribonucleic acid
ECM Extracellular matrix
EGF Epidermal growth factor
EGR-1 Early growth response protein 1
ERK Extracellular signal-regulated kinase
FGF Fibroblast growth factor
GRADE Grading of Recommendations Assessment, Development and Evaluation
HB-EGF Heparin-binding epidermal growth factor
HIF-1α Hypoxia-inducible factor 1 alpha
HO-1 Heme oxygenase 1
IF Immunofluorescence
IGF-I Insulin-like growth factor I
IHC Immunohistochemistry
IL Interleukin
IP3 Inositol 1,4,5-trisphosphate
IWGDF International Working Group on the Diabetic Foot
MAPK Mitogen-activated protein kinase
MD Mean difference
MDA Malondialdehyde
MEK Mitogen-activated protein kinase kinase
MeSH Medical Subject Headings
MMP Matrix metalloproteinase
NF-κB Nuclear factor kappa B
NLRP3 NLR family pyrin domain-containing protein 3
NOD Non-obese diabetic
NR Not reported
Nrf2 Nuclear factor erythroid 2-related factor 2
OSF Open Science Framework
PBS Phosphate-buffered saline
PCNA Proliferating cell nuclear antigen
PDGF Platelet-derived growth factor
PDGF-BB Platelet-derived growth factor-BB
PDGFR Platelet-derived growth factor receptor
PEG Polyethylene glycol
PICOS Population, Intervention, Comparator, Outcomes, and Study Design
PI3K Phosphoinositide 3-kinase
PIP3 Phosphatidylinositol 3,4,5-trisphosphate
PLGA Poly(lactic-co-glycolic acid)
PLC-γ Phospholipase C gamma
PRISMA Preferred Reporting Items for Systematic Reviews and Meta-Analyses
RAF Rapidly accelerated fibrosarcoma kinase
RAGE Receptor for advanced glycation end-products
RAS Rat sarcoma small gtpase
REML Restricted maximum likelihood
rhPDGF-BB Recombinant human platelet-derived growth factor-BB
ROS Reactive oxygen species
SOD1 Superoxide dismutase 1
STZ Streptozotocin
SWiM Synthesis Without Meta-Analysis
SYRCLE Systematic Review Centre for Laboratory Animal Experimentation
TGF Transforming growth factor
TIMP Tissue inhibitor of metalloproteinases
VEGF Vascular endothelial growth factor
WRAHPS Wound Reporting in Animal and Human Preclinical Studies