AB	Diblock copolymer (A–B architecture)
ABA	Triblock copolymer (A–B–A architecture)
AI	Artificial intelligence
APS	Amorphous phase separation
ASD	Amorphous solid dispersion
AuNP	Gold nanoparticle
BBB	Blood–brain barrier
BCS	Biopharmaceutics classification system
BPNP	Biodegradable polymeric nanoparticle
CMC	Critical micelle concentration
CNS	Central nervous system
CS	Chitosan
DOX	Doxorubicin
EDY	Maleimidenediyne
FDA	U.S. Food and Drug Administration
FIH	First-in-human
FNP	Functionalized nanoparticle
GBM	Glioblastoma
GEM	Gemcitabine
H1–H8	Translational hurdles 1–8
HPMC	Hydroxypropyl methylcellulose
HPMCAS	Hydroxypropyl methylcellulose acetate succinate
LNP	Lipid nanoparticle
MRI	Magnetic resonance imaging
MTD	Maximum tolerated dose
NLC	Nanostructured lipid carrier
NP	Nanoparticle
PCL	Polycaprolactone
PD-L1	Programmed death-ligand 1
PEG	Polyethylene glycol
PET	Positron emission tomography
PK	Pharmacokinetics
PLA	Polylactic acid
PLGA	Poly(lactic-co-glycolic acid)
PM	Polymeric micelle
PMPC	Poly(2-methacryloyloxyethyl phosphorylcholine)
PVA	Polyvinyl alcohol
PVDF	Polyvinylidene fluoride
PVP	Polyvinylpyrrolidone
RNAi	RNA interference
SCARA5	Scavenger receptor class A member 5
SLN	Solid lipid nanoparticle
SPECT	Single photon emission computed tomography
TfR1	Transferrin receptor 1
Tg	Glass transition temperature
TIM-2	T-cell immunoglobulin and mucin domain 2