Act	Activity
AD	applicability domain
AUC	Areas Under the Curve
BZN	benznidazole
CD	Chagas disease
CA	cluster analyses
CV	cyclic voltammetry
DNDi	Drugs for Neglected Diseases initiative
EPR	electron paramagnetic resonance
ESR	Electron Spin Resonance
HMDE	hanging mercury drop electrode
HOMO	highest occupied molecular orbital
IC50	half-maximal inhibitory concentration
k-NNCA	k nearest-neighbor cluster analysis
k-MCA	k-means cluster analysis
LUMO	lowest unoccupied molecular orbital
NFX	nifurtimox
PS	prediction set
QSARs	quantitative structure–activity relationships
RF	Random Forest
ROS	reactive oxygen species
ROC	Receiver Operating Characteristic
SHAP	Shapley Additive Explanations
SD	standard deviation
TS	training set
TcNTRs	T. cruzi nitroreductases