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. 2026 Aug 26;18(9):1069. doi: 10.3390/pharmaceutics18091069
AD Atopic dermatitis
AhR Aryl hydrocarbon receptor
AKBA 3-Acetyl-11-keto-β-boswellic acid
AUC Area under the concentration–time curve
AUC0–24 h Area under the concentration–time curve from 0 to 24 h
BSA Bovine serum albumin
CD/CDs Cyclodextrin(s)
Cmax Maximum plasma concentration
CMCs Critical micelle concentrations
CPE/CPEs Chemical permeation enhancer(s)
DBMNP/DBMNPs Dissolved bubble microneedle patch(es)
DEGEE Diethylene glycol monoethyl ether
DMN/DMNs Dissolving microneedle(s)
DMSO Dimethyl sulfoxide
DNA Deoxyribonucleic acid
DPG Dipotassium glycyrrhizinate
E1 In vitro release, permeation, reconstructed-skin, or synthetic-membrane evidence
E2 Ex vivo animal- or human-skin evidence
E3 In vivo animal pharmacokinetic, tissue-distribution, efficacy, or safety evidence
E4 Human pharmacokinetic, dermatokinetic, tissue-deposition, or mechanistic evidence
E5 Controlled clinical evidence in humans
E6 Regulatory approval or established commercial use
EMLA Eutectic mixture of local anesthetics
ERflux Flux enhancement ratio
Er:YAG Erbium-doped yttrium aluminum garnet
EU European Union
EV/EVs Extracellular vesicle(s)
FDA U.S. Food and Drug Administration
FITC Fluorescein isothiocyanate
FOXM1 Forkhead box M1
GAIS Global Aesthetic Improvement Scale
G-CSF Granulocyte colony-stimulating factor
GelMA Gelatin methacryloyl
GFP Green fluorescent protein
HAMA Hyaluronic acid methacrylate
HbA1c Glycated hemoglobin A1c
HPC Hydroxypropyl cellulose
HPMC Hydroxypropyl methylcellulose
IFN-γ Interferon gamma
IGA Investigator Global Assessment
IGA-CHE Investigator Global Assessment for chronic hand eczema
IPM Isopropyl myristate
JAK Janus kinase
LHRH Luteinizing hormone-releasing hormone
logD Logarithm of distribution coefficient
LogP Logarithm of partition coefficient
L-Pro2 N-acetyl-L-proline dodecyl ester
MC Methylcellulose
MCP-1 Monocyte chemoattractant protein-1
MN/MNs Microneedle(s)
MP Methyl paraben
mPASI Modified Psoriasis Area and Severity Index
mRNA Messenger RNA
MRT Mean residence time
MSC Mesenchymal stem cell(s)
MW Molecular weight
NaCMC Sodium carboxymethyl cellulose
NIR Near-infrared
NMP N-methyl-2-pyrrolidone
NSAID Nonsteroidal anti-inflammatory drug
PBS Phosphate-buffered saline
PD-L1 Programmed death-ligand 1
PEG/PEGs Polyethylene glycol(s)
PG Propylene glycol
PRISMA Preferred Reporting Items for Systematic Reviews and Meta-Analyses
PVP Polyvinylpyrrolidone
Q24 Cumulative amount permeated at 24 h
ROS Reactive oxygen species
SC Stratum corneum
SEMA Semaglutide
sEV/sEVs Small extracellular vesicle(s)
siRNA Small interfering RNA
SLN/SLNs Solid lipid nanoparticle(s)
SLS Sodium lauryl sulfate
t1/2 Elimination half-life
TEWL Transepidermal water loss
TGF-β1 Transforming growth factor beta 1
TPGS D-α-tocopheryl polyethylene glycol 1000 succinate
TRV/TRVs Tiered-release vesicle(s)