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. 2026 Sep 15;18(9):1154. doi: 10.3390/pharmaceutics18091154
aGVHD Acute graft-versus-host disease
AI Artificial intelligence
ALL Acute lymphoblastic leukemia
AML Acute myeloid leukemia
AUC Area under the concentration–time curve
AUC6 AUC over a 6 h dosing interval
AUC12 AUC over a 12 h dosing interval
AUC24 AUC over a 24 h dosing interval
AUC96 Cumulative area under the concentration–time curve over 96 h
AUCcum Cumulative area under the concentration–time curve
BD Twice daily
BSA Body surface area
Bu Busulfan
CL Clearance
Cmax Maximum concentration
Css Steady-state concentration
CYP Cytochrome P450
DNA Deoxyribonucleic acid
EBMT European Society for Blood and Marrow Transplantation
EFS Event-free survival
EMA European Medicines Agency
FDA United States Food and Drug Administration
FMO Flavin-containing monooxygenase
GC Gas chromatography
GRFS Graft-versus-host disease-free, relapse-free survival
GSG γ-glutamyl-dehydroalanyl-glycine–glutathione S-conjugate
GSH Glutathione
GST Glutathione S-transferase
GSTA1 Glutathione S-transferase alpha 1
GSTA2 Glutathione S-transferase alpha 2
GSTM1 Glutathione S-transferase mu 1
GSTP1 Glutathione S-transferase pi 1
GSTT1 Glutathione S-transferase theta 1
GVHD Graft-versus-host disease
HPLC High-performance liquid chromatography
HSCT Hematopoietic stem cell transplantation
IEI Inborn errors of immunity
IIV Interindividual variability
IOV Inter-occasion variability
LC–MS/MS Liquid chromatography–tandem mass spectrometry
LSS Limited sampling strategy
MDS Myelodysplastic syndrome
MIPD Model-informed precision dosing
ML Machine learning
NCA Noncompartmental analysis
NLME Nonlinear mixed-effects modeling
NRM Non-relapse mortality
OFV Objective function value
OS Overall survival
PBPK Physiologically based pharmacokinetic
PK Pharmacokinetic/pharmacokinetics
PK/PD Pharmacokinetic/pharmacodynamic
PopPK Population pharmacokinetic
QD Once daily
QID Four times daily
RIC Reduced-intensity conditioning
RUV Residual unexplained variability
TBI Total body irradiation
TDM Therapeutic drug monitoring
THT Tetrahydrothiophene
UCBT Unrelated umbilical cord blood transplantation
VOD/SOS Hepatic veno-occlusive disease/sinusoidal obstruction syndrome