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Effects of DHT on caspase activity in LNCaP-si-E6 (mock transfectant) and LNCaP-si-p53. Cells were pretreated for 48 h with indicated concentrations of DHT and then treated for 3 h with wortmannin (1 μm) plus TNF-α (20 ng/ml) or with wortmannin plus TRAIL (100 ng/ml). Caspase activity was estimated in cell lysates with the substrate Ac-DEVD-AMC
