Table 9.
Meta-Analysis of Immune Responses to Major and Minor Life Events of Unknown Duration in Healthy Participants
| Immune marker | k | N | r | SEr | 95% CI | p | Q |
|---|---|---|---|---|---|---|---|
| Leukocyte subset count | |||||||
| Lymphocytes | 5 | 537 | −.18 | .17 | −.47, .14 | .27 | 20.28*** |
| T lymphocytes | 4 | 237 | .00 | .07 | −.13, .13 | .99 | 0.00 |
| T-helper lymphocytes | 5 | 227 | .00 | .07 | −.13, .13 | .99 | 0.00 |
| T-cytotoxic lymphocytes | 5 | 227 | .05 | .07 | −.09, .18 | .48 | 3.02 |
| T-helper:T-cytotoxic ratio | 3 | 70 | .14 | .38 | −.54, .71 | .71 | 12.11** |
| Natural killer cells | 4 | 194 | −.08 | .07 | −.22, .07 | .28 | 2.72 |
| Leukocyte subset percentage | |||||||
| T lymphocytes | 3 | 151 | .20 | .21 | −.21, .55 | .34 | 7.61* |
| T-helper lymphocytes | 7 | 285 | .01 | .06 | −.11, .13 | .83 | 0.54 |
| T-cytotoxic lymphocytes | 6 | 205 | −.01 | .07 | −.15, .14 | .92 | 0.07 |
| Natural killer cells | 5 | 261 | .00 | .06 | −.12, .12 | .99 | 0.00 |
| Total immunoglobulins | |||||||
| Serum IgA | 3 | 124 | −.07 | .10 | −.26, .14 | .52 | 2.19 |
| Serum IgG | 3 | 124 | −.06 | .10 | −.24, .13 | .54 | 2.06 |
| Serum IgM | 3 | 124 | .03 | .09 | −.15, .21 | .72 | 0.72 |
| Secretory IgA rate | 3 | 276 | −.08 | .10 | −.26, .11 | .43 | 3.97 |
| Secretory IgA concentration | 4 | 101 | −.16 | .14 | −.42, .12 | .25 | 4.34 |
| Specific immunoglobulin | |||||||
| Epstein-Barr virus | 3 | 317 | −.02 | .11 | −.23, .19 | .86 | 5.65 |
| Natural killer cell function | |||||||
| Natural killer cell cytotoxicity | 12 | 672 | −.07 | .07 | −.20, .07 | .35 | 29.39*** |
| Lymphocyte proliferation | |||||||
| Proliferation to ConA | 3 | 72 | −.13 | .15 | −.35, .16 | .38 | 2.49 |
| Proliferation to PHA | 4 | 131 | −.26 | .15 | −.50, .03 | .08 | 6.11 |
Note. CI = confidence interval; IgA = immunoglobulin A; IgG = immunoglobulin G; IgM = immunoglob-ulin M; ConA = concanavalin A; PHA = phytohemagglutinin.
*
p < .05.
**
p < .01.
***
p < .001.