TABLE 1.

Production of human cytokines by TPA-induced BC-3 cells treated with different doses of MTX

MTX dose (nM)	TPA	Cytokine concn (pg/ml)
		IL-10	IL-12	IL-1β	IL-6	IL-8	TNF-α
0	−	210	3.1	0	238	2.1	43.6
0	+	207	0	0	247	27.1	42.8
1	+	206	0	0	247	26.1	19.4
5	+	207	0	0	244	32.8	13.2
10	+	207	0	0	247	25.6	10.2
50	+	207	0	0	245	37.4	14.7
100	+	205	0	0	249	31.1	9.20
500	+	205	0	0	252	28.8	13.4
1,000	+	203	0.95	0	247	22.7	3.10