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. 2026 Sep 22;19:607359. doi: 10.2147/CCID.S607359

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© 2026 Zhang et al.

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A forest plot comparing odds ratios across methods for omega 6 over omega 3, omega 3 and DHA. A forest plot with a table and confidence interval markers for three main outcomes: omega 6 over omega 3, omega 3 and DHA. Columns are labeled, Main.outcome, Method, nSNP, P value and OR(95 percentCI). The odds ratio axis is labeled from 0 to 3, with tick marks at 0, 1, 2 and 3 and a vertical reference line at 1. Text under the axis reads, protective factor, on the left and, risk factor, on the right. For omega 6 over omega 3: MR Egger, nSNP 24, P value 0.006384581, odds ratio 1.53 with 95 percent confidence interval 1.16 to 2.01. Weighted median, 24, 0.000703384, 1.45 with 1.17 to 1.80. Inverse variance weighted, 24, 0.039339726, 1.26 with 1.01 to 1.57. Simple mode, 24, 0.212683261, 1.58 with 0.78 to 3.20. Weighted mode, 24, 0.003468508, 1.41 with 1.15 to 1.72. For omega 3: MR Egger, 44, 0.068290968, 0.73 with 0.53 to 1.01. Weighted median, 44, 0.000197792, 0.67 with 0.54 to 0.82. Inverse variance weighted, 44, 0.039109564, 0.78 with 0.62 to 0.99. Simple mode, 44, 0.011329303, 0.39 with 0.19 to 0.78. Weighted mode, 44, 0.001770620, 0.70 with 0.57 to 0.87. For DHA: MR Egger, 35, 0.146282491, 0.74 with 0.49 to 1.10. Weighted median, 35, 0.000412086, 0.62 with 0.47 to 0.81. Inverse variance weighted, 35, 0.004264756, 0.66 with 0.50 to 0.88. Simple mode, 35, 0.268976129, 0.63 with 0.28 to 1.41. Weighted mode, 35, 0.001210600, 0.65 with 0.51 to 0.83. A note at bottom states p less than 0.05 was considered statistically significant. — All single-factor analysis of variance for unsaturated fatty acids.