Table 1.

Summary of data sources

Study ID-Year	Study Design	Breed	Age, yr	No.Sex	BW (kg)	Dosing Route	Dosage, Form	Data Type
1-1981	Randomized, cross-over	Saddlebred	7 ~ 15	1 F/5 G	484 ~ 700	IV	0.05 mg/kg DEX	DEX and CTS in plasma (Start at 7 ~ 9 AM), DEX in urine
							0.05 mg/kg DEX_ISO
2-2010	Single-dose, parallel	Standardbred	3 ~ 16	6 G	430 ~ 545	IM	0.0237 mg/kg DEX_ISO	DEX, CTS in plasma (Start at 9 AM), DEX in urine, CTS baseline
3-2012	Randomized, multi-period, cross-over	Standardbred	6 ~ 20	4 F/2 G	430 ~ 584	IV	0.1 µg/kg + 0.0233 µg/kg/h*3 h DEX_PHO	DEX, CTS in plasma (Start at 9:30 ~ 10:30 AM), CTS baseline
							1 µg/kg + 0.233 µg/kg/h*3 h
							10 µg/kg + 2.33 µg/kg/h*3 h
4-2007	Randomized, cross-over	Saddlebred	5 ~ 17	2 F/6 G	430 ~ 618	IV	0.008 mg/kg DEX	DEX in plasma and urine
5-2013	Randomized, placebo-controlled, cross-over	Standardbred	3 ~ 9	3 F/3 G	431 ~ 538	IA	0.01 mg DEX_PHO	DEX and CTS in plasma (Start at 11:30 AM), CTS baseline
							0.1 mg DEX_PHO
							1 mg DEX_PHO
							0.03 mg DEX_PHO	DEX and CTS in plasma (Start at 11 AM), CTS baseline
							0.3 mg DEX_PHO
							3 mg DEX_PHO

IV, intravenous; IM, intramuscular; IA, intra-articular; DEX_ISO, DEX isonicotinate; DEX_PHO, DEX sodium phosphate; CTS, cortisol. Sex: F = Mare (Female), G = gelding

All dosages are DEX-equivalents