Figure 6.

Dimer interface sequence alignments of putative dimeric MTases. The sequences of M.RsrI, M.MboIIA, M2.DpnII, M.HpaI and M.BglII were aligned using ClustalW with its default settings; only the region of the dimer interface is shown. Black letters indicate completely conserved amino acids, striped letters are similar amino acids and light gray letters are unconserved. Conserved amino acids participating in the dimer interface identified by comparison of M.RsrI and M.MboIIA are in red boxes; additional interfacial amino acids identified as conserved in all five MTases are colored blue. Unconserved amino acids involved in the dimer interface of M.RsrI are colored yellow.