Table 1.

Protein sets

Protein set	Description
All yeast	All yeast proteins
Non acts	All yeast proteins not in the activator list
TR	Known transcriptional activators/regulators (GO slim term ‘transcription activator activity’)
All acts	All Y2H activators
Nucleus	Nuclear proteins [Huh et al. (33)]
Acts nucleus	Y2H activators localized to the nucleus
LTHw, LTHm, LTHs	Weak (LTHw), medium (LTHm), and strong (LTHs) activators in LTH assay
TR+1, nucleus+1, acts nucleus+1	Protein sets as indicated above but including directly interacting proteins in the analysis of binary protein interactions.