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. 2026 Sep 14;16:1854567. doi: 10.3389/fonc.2026.1854567

Table 2.

Sociodemographic and clinical melanoma characteristics by prevalent tumor status.

Variable Overall dataset
(n = 2978)
Prevalent tumors p-value
Absent (n = 2844) Present (n = 134)
Sex 0.001a
 Female 42.5% (1267) 1229 (43.2%) 38 (28.4%)
 Male 57.5% (1711) 1615 (56.8%) 96 (71.6%)
Age <0.001b
 Median[IQR] 63.0 [51.0;75.0] 62.0 [51.0;74.0] 73.5 [65.0;81.0]
 Mean(std) 62.6 (15.4) 62.2 (15.4) 71.7 (11.2)
Age groups <0.001a
 <45 12.7% (377) 375 (13.2%) 2 (1.5%)
 45-54 19.0% (567) 560 (19.7%) 7 (5.2%)
 55-64 20.9% (623) 600 (21.1%) 23 (17.2%)
 65-74 22.1% (657) 619 (21.8%) 38 (28.4%)
 75-84 18.8% (560) 509 (17.9%) 51 (38.1%)
 >84 6.5% (194) 181 (6.4%) 13 (9.7%)
Breslow 0.232a
 < 0.76 mm 55.5% (1564) 1505 (55.8%) 59 (48.0%)
 0.76 – 1.75 mm 21.6% (608) 577 (21.4%) 31 (25.2%)
 > 1.75 mm 23.0% (648) 615 (22.8%) 33 (26.8%)
 Missing 158 147 11
Numerical Breslow 0.095b
 Median[IQR] 0.7 [0.4;1.6] 0.6 [0.4;1.6] 0.8 [0.4;2.0]
 Mean(std) 1.7 (3.0) 1.7 (3.0) 1.8 (2.3)
 Missing 158 147 11
Ulcerations 0.460a
 Absent 80.2% (2265) 2168 (80.3%) 97 (77.6%)
 Present 19.8% (560) 532 (19.7%) 28 (22.4%)
 Missing 153 144 9
T 0.074c
 T0 1.3% (38) 33 (1.2%) 5 (3.9%)
 T1 64.8% (1874) 1800 (65.2%) 74 (57.4%)
 T2 13.1% (379) 361 (13.1%) 18 (14.0%)
 T3 10.6% (306) 289 (10.5%) 17 (13.2%)
 T4 10.1% (293) 278 (10.1%) 15 (11.6%)
 Missing 88 83 5
N 0.294c
 N0 88.4% (2426) 2328 (88.7%) 98 (83.8%)
 N1 7.4% (202) 190 (7.2%) 12 (10.3%)
 N2 2.9% (79) 74 (2.8%) 5 (4.3%)
 N3 1.3% (36) 34 (1.3%) 2 (1.7%)
 Missing 235 218 17
M 0.521c
 M0 95.7% (2733) 2611 (95.7%) 122 (94.6%)
 M1 4.3% (123) 116 (4.3%) 7 (5.4%)
 Missing 122 117 5
TNM stage 0.180a
 I 72.5% (2080) 1996 (72.9%) 84 (64.1%)
 II 13.8% (396) 372 (13.6%) 24 (18.3%)
 III 9.3% (267) 251 (9.2%) 16 (12.2%)
 IV 4.4% (126) 119 (4.3%) 7 (5.3%)
 Missing 109 106 3
Tumor’s histologic type 0.491c
 Superficial spreading melanoma 53.8% (1596) 1530 (54.0%) 66 (50.0%)
 Malignant melanoma 29.0% (861) 823 (29.1%) 38 (28.8%)
 Nodular melanoma 11.2% (333) 314 (11.1%) 19 (14.4%)
 Lentigo maligna 2.3% (69) 67 (2.4%) 2 (1.5%)
 Acral-lentiginous melanoma 1.2% (35) 32 (1.1%) 3 (2.3%)
 Spitzoid melanoma 0.9% (26) 25 (0.9%) 1 (0.8%)
 Melanoma arising from blue naevus 0.8% (25) 24 (0.8%) 1 (0.8%)
 Desmoplastic melanoma 0.7% (20) 18 (0.6%) 2 (1.5%)
 Missing 13 11 2
Tumor’s site 0.617c
 Trunk 48.7% (1420) 1359 (48.8%) 61 (48.4%)
 Lower limbs 21.9% (639) 615 (22.1%) 24 (19.0%)
 Upper limbs 16.7% (486) 460 (16.5%) 26 (20.6%)
 Head and neck 12.6% (368) 353 (12.7%) 15 (11.9%)
 Missing 65 57 8

aPearson’s Chi-squared test, bMann-Whitney test, cFisher’s Exact Test for Count Data.