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Bioactivities of triptolide (TPL) and its analogs
| Entry | Name | Structure | IC50 (μM), XPB activity |
IC50 (μM), DCTPP1 activity |
IC50 (nM), DU145 growth |
IC50 with 50 nM DAC (nM), DU145 growth |
|---|---|---|---|---|---|---|
| 1 | TPL |  |
0.145 | 10.0 | 0.448 | 0.219 |
| 2 | TPL-2004 |  |
1.44 | 3.10 | 6.05 | 1.60 |
| 3 | TPL-2005 |  |
0.156 | 22.4 | 0.766 | 0.675 |
| 4 | TPL-2015 |  |
2.90 | >1000 | 8.71 | 9.78 |
| 5 | TPL-2021 |  |
10.1 | 60.0 | 8.55 | 2.07 |
| 6 | TPL-2024 |  |
100 | >1000 | 3330 | 864 |
