Table 3.

Association between complement activation index (CAI) and the composite renal outcome.

Exposure	Non-adjusted		Adjust I		Adjust II
	HR (95% CI)	P Value	HR (95% CI)	P Value	HR (95% CI)	P Value
CAI (per 1 point increase)	3.07 (1.94–4.88)	<0.001	2.63 (1.64–4.22)	<0.001	1.87 (1.10–3.20)	0.021
Low CAI (Score 0–1)	1.0 (Reference)		1.0 (Reference)		1.0 (Reference)
High CAI (Score 2–3)	5.42 (2.51–11.68)	<0.001	4.57 (2.10–9.96)	<0.001	2.58 (1.15–5.80)	0.022

Non-adjusted model: Adjusted for none.

Adjusted I model: Adjusted for gender, age, hypertension history, and diabetes mellitus history.

Adjusted II model: Adjusted for gender, age, hypertension history, diabetes mellitus history, eGFR, UPRO, M, E, S, T, and immunosuppressive regimen.

P values are nominal. Models 1–3 represent sequential adjustment for the same underlying exposure-outcome association rather than independent hypothesis tests. Primary inference was based on the High versus Low CAI comparison in the fully adjusted model. Continuous CAI was a prespecified secondary analysis of dose-response.