Table 3.

Gene ontology (GO) categories of human genes overlapping TFRs

GO	Description	Na	Expb	Obsc	Foldd	Pe
Molecular function:
GO:0003700	transcription factor activity	786	38	167	4.4	<10-66
GO:0030528	transcription regulator activity	1106	53	195	3.6	<10-63
GO:0003677	DNA binding	1755	85	235	2.8	<10-55
GO:0003676	nucleic acid binding	2764	134	286	2.1	<10-45
Biological process:
GO:0045449	regulation of transcription	1738	83	244	2.9	<10-64
GO:0019219	regulation of nucleic acid metabolism	1762	85	244	2.9	<10-62
GO:0006355	regulation of transcription, DNA-dependent	1665	80	233	2.9	<10-60
GO:0006350	transcription	1818	87	244	2.8	<10-59
GO:0031323	regulation of cellular metabolism	1874	90	246	2.7	<10-58
GO:0006351	transcription, DNA-dependent	1720	83	234	2.8	<10-58
GO:0019222	regulation of metabolism	1927	92	247	2.7	<10-56
GO:0050789	regulation of biological process	2929	141	301	2.1	<10-50
GO:0050794	regulation of cellular process	2731	131	287	2.2	<10-49
GO:0050791	regulation of physiological process	2682	129	283	2.2	<10-48
GO:0051244	regulation of cellular physiological process	2599	125	277	2.2	<10-48
GO:0007275	development	1723	83	201	2.4	<10-37
GO:0009653	morphogenesis	1088	52	130	2.5	<10-24
GO:0009887	organogenesis	850	41	103	2.5	<10-19
GO:0048513	organ development	903	43	104	2.4	<10-18
GO:0007399	neurogenesis	389	19	61	3.3	<10-16

^aTotal number of genes in genome assigned to this GO category

^bExpected number of genes overlapping with TFRs

^cObserved number of genes overlapping with TFRs

^dFold enrichment of observed over expected

^eP-values