Skip to main content
letter
. 2006 Feb;16(2):173–181. doi: 10.1101/gr.4456006

Table 2.

Strict paralogous gene pairs (reciprocal best BLAST matches) present on human DNA segments with increased copy number relative to chimpanzee and gorilla

Gene 1 Chr Start End Description Gene 2 Chr Start End Description dN dS dN/dS P(1.0) P(0.5)
ENSG00000186301 1 16,353,203 16,360,133 Similar to macrophage stimulating 1 (hepatocyte growth factor-like) ENSG00000186715 1 16,462,486 16,468,660 No description 0.233 0.843 0.276 0.000 0.000
ENSG00000051415 1 103,423,056 103,655,958 α-Amylase, salivary precursor ENSG00000174876 1 103,584,694 103,592,978 α-Amylase salivary precursor 0.015 0.061 0.245 0.000 0.044
ENSG00000132043 1 146,102,223 146,214,718 No description ENSG00000168614 1 145,923,370 145,958,684 No description 0.268 0.260 1.032 0.694 0.000
ENSG00000182639 1 147,000,080 147,000,460 Histone H2B.J ENSG00000184678 1 147,074,392 147,074,772 Histone H2B.Q 0.004 0.188 0.021 0.001 0.004
ENSG00000183598 1 147,001,408 147,001,818 H3 histone family 2; H3 histone family, member M ENSG00000183702 1 147,040,763 147,042,418 H3 histone, family 2; H3 histone family, member M 0.000 0.418 0.001 0.000 0.000
ENSG00000183558 1 147,030,455 147,030,847 Histone H2A.O ENSG00000183717 1 147,039,210 147,039,773 Histone H2A.O 0.000 0.001 0.387 0.758 0.811
ENSG00000182217 1 147,047,334 147,049,286 Histone H4 ENSG00000183941 1 147,020,824 147,022,776 Histone H4 0.001 0.000 0.797 0.743
ENSG00000169769 2 89,344,195 89,344,735 IG κ chain V-III region NG9 precursor ENSG00000184817 2 87,540,174 87,540,735 No description 0.051 0.061 0.839 0.749 0.324
ENSG00000173756 2 89,423,308 89,423,634 IG κ chain V-II region GM607 precursor ENSG00000182563 2 89,330,327 89,330,632 No description 0.092 0.237 0.388 0.014 0.500
ENSG00000131426 2 89,897,439 89,897,914 IG κ chain V-I region HK 101 precursor ENSG00000163245 2 89,301,505 89,301,971 IG κ chain V-I region 0.027 0.029 0.903 0.888 0.403
ENSG00000172038 2 89,912,079 89,912,595 IG κ chain V-III region CLL precursor (rheumatoid factor) ENSG00000186192 2 89,058,824 89,248,127 IG κ chain C region 0.045 0.098 0.459 0.116 0.858
ENSG00000163184 2 89,957,240 89,957,539 IG κ chain V-I region ENSG00000186856 2 89,062,541 89,242,332 No description 0.000 0.021 0.001 0.040 0.105
ENSG00000169606 2 132,594,457 132,595,857 No description ENSG00000172981 22 14,635,352 14,636,482 No description 0.031 0.165 0.191 0.000 0.001
ENSG00000154927 2 132,690,833 132,735,739 No description ENSG00000186825 2 132,763,505 132,764,092 No description 0.000 0.006 0.001 0.118 0.210
ENSG00000177631 4 49,320 78,099 No description ENSG00000182141 22 15,009,448 15,026,562 No description 0.327 0.582 0.562 0.000 0.003
ENSG00000184671 5 69,006,181 69,062,049 Baculoviral IAP repeat-containing protein 1 (neuronal apoptosis inhibitory protein) ENSG00000185284 5 69,659,709 69,678,715 No description 0.036 0.113 0.318 0.000 0.051
ENSG00000182078 5 69,234,613 69,234,750 No description ENSG00000186932 5 70,293,834 70,293,971 No description 0.000 0.001 0.001 0.766 0.874
ENSG00000183666 5 69,498,165 69,537,080 No description ENSG00000183761 5 69,239,339 69,301,070 No description 0.000 0.001 0.000 0.682 0.832
ENSG00000180027 5 70,249,240 70,289,288 SMA3 protein ENSG00000185759 5 69,997,497 70,038,832 SMA3 protein 0.000 0.001 0.410 0.730 0.813
ENSG00000174133 5 70,271,857 70,276,207 No description ENSG00000186361 5 70,010,592 70,014,942 No description 0.039 0.026 1.514 0.001 0.000
ENSG00000170135 7 73,622,573 73,679,914 Transcription factor GTF2IRD2 ENSG00000174428 7 73,962,893 73,977,192 Transcription factor GTF2IRD2 0.052 0.099 0.524 0.002 0.820
ENSG00000123965 7 73,718,985 73,733,868 Postmeiotic segregation increased 2-like 5 ENSG00000135165 7 71,762,053 75,683,468 Zona pellucida sperm-binding protein 3 precursor 0.007 0.009 0.793 0.802 0.611
ENSG00000165178 7 73,984,535 73,999,836 No description ENSG00000182487 7 72,046,778 72,062,076 No description 0.003 0.023 0.137 0.007 0.072
ENSG00000181881 7 143,339,071 143,443,973 No description ENSG00000181926 7 143,383,314 143,389,573 No description 0.000 0.000 0.858 0.991 0.832
ENSG00000170341 7 143,406,977 143,407,891 Seven transmembrane helix receptor ENSG00000170356 7 143,320,745 143,321,671 Seven transmembrane helix receptor 0.000 0.004 0.001 0.104 0.189
ENSG00000106714 9 39,063,817 39,278,466 Contactin associated protein-like 3 precursor (cell recognition molecule CASPR3) ENSG00000154529 9 39,704,516 39,839,734 No description 0.009 0.020 0.422 0.229 0.809
ENSG00000147926 9 39,908,370 39,912,422 No description ENSG00000182355 9 39,345,699 39,351,955 No description 0.009 0.006 1.560 0.295 0.005
ENSG00000179828 9 40,483,601 40,501,134 No description ENSG00000182153 9 41,776,397 41,793,931 No description 0.000 0.003 0.001 0.154 0.261
ENSG00000170165 9 43,977,955 43,988,544 No description ENSG00000176057 9 43,907,570 43,918,159 No description 0.000 0.003 0.001 0.147 0.251
ENSG00000170161 9 63,660,398 63,661,000 No description ENSG00000186383 9 41,506,025 41,506,582 No description 0.015 0.055 0.269 0.091 0.420
ENSG00000176299 14 18,238,610 18,239,551 Seven transmembrane helix receptor ENSG00000182974 15 19,866,208 19,867,149 Seven transmembrane helix receptor 0.029 0.028 1.034 0.942 0.097
ENSG00000176294 14 18,285,736 18,286,659 Seven transmembrane helix receptor ENSG00000183706 15 19,880,105 19,881,055 Seven transmembrane helix receptor 0.077 0.191 0.402 0.000 0.356
ENSG00000175733 15 21,016,715 21,019,583 No description ENSG00000184095 15 19,057,902 19,060,769 No description 0.083 0.091 0.913 0.756 0.025
ENSG00000128731 15 25,958,549 26,169,609 HECT domain and RLD 2 ENSG00000140181 15 20,829,990 20,883,368 No description 0.020 0.034 0.599 0.017 0.391
ENSG00000153684 15 26,233,151 26,236,568 No description ENSG00000183629 15 26,495,524 26,498,941 No description 0.000 0.001 0.001 0.590 0.671
ENSG00000169861 16 32,106,704 32,113,996 No description ENSG00000182414 16 32,009,310 32,099,878 IG heavy chain V-III region 0.305 0.533 0.572 0.036 0.611
ENSG00000183677 18 42,811,361 42,813,622 RNA polymerase II transcription factor SIII subunit A2 (elongin A2) ENSG00000183791 18 42,806,560 42,808,200 RNA polymerase II transcription factor SIII subunit A3 (elongin A3) 0.070 0.085 0.825 0.381 0.018
ENSG00000130538 22 14,823,378 14,824,325 No description ENSG00000186445 14 18,171,223 18,172,203 Seven transmembrane helix receptor 0.008 0.000 0.066 0.016
ENSG00000185912 Y 8,898,452 8,960,986 Testis-specific Y-encoded protein ENSG00000187194 Y 9,000,204 9,001,613 No description 0.052 0.126 0.412 0.089 0.699
ENSG00000131007 Y 19,638,276 19,645,782 Transcript Y 9 protein ENSG00000131009 Y 19,788,761 19,796,267 Transcript Y 9 protein 0.000 0.002 0.001 0.821 0.941
ENSG00000169953 Y 19,788,522 19,830,805 Heat shock transcription factor, Y-linked ENSG00000172468 Y 19,603,741 19,646,021 Heat shock transcription factor, Y-linked 0.000 0.002 0.001 0.601 0.633

Gene identifiers, coordinates, and descriptions are from the Ensembl database (v. 27.35a) and are based on the NCBI_34 genome build. P-values for likelihood ratios are given for observed dN/dS compared to a null dN/dS of 1.0 or 0.5, respectively.