Figure 1.

Schematic representation of a dual coding region in the human ITGB4BP gene. Exons are represented by boxes, and introns are represented by connecting lines. Numbers inside the boxes refer to base pairs. Roman numerals indicate intron phases. The dual coding region is marked by a black horizontal arrow. Orthologous sequences for this region are shown in other species, and in-frame stop codons are marked by an underlined X. Based on this alignment, the table on the right summarizes the presence of stop codons in two reading frames. Bioinformatic supporting evidence for both reading frames is shown in the table on the left. White arrows indicate direction of data flow. NM_181466 and NM_181467 are RefSeq accession numbers.