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. Author manuscript; available in PMC: 2006 Feb 8.
Published in final edited form as: Cancer Biol Ther. 2005 Dec 23;4(12):1401–1408. doi: 10.4161/cbt.4.12.2355

Fig. 2.

Fig. 2

Low-level expression of KLF4 induces epithelial turnover without overt hyperplasia. Transgenic animals carrying the reverse tetracycline-responsive transcriptional activator (rtTA) under control of the MMTV promoter (i.e., MMTV-rtTA) were crossed with tetracycline response element (TRE)-KLF4 transgenic mice, and bitransgenic offspring were induced with dox (upper panels). Paraffin sections of skin were analyzed by immunostaining. Control animals were administered sucrose-water without dox. As an additional control, animals expressing KLF4 under control of a K14-rtTA transgene were induced and analyzed in parallel (lower panels). Closed arrows indicate the DEJ, and open arrows indicate follicle epithelium. Scale bars, 50μ.