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. 2006 Feb 10;2(2):e17. doi: 10.1371/journal.pgen.0020017

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© 2006 Wong et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A total of 75 CpG orphans were selected from 25 sites (Op-1 to Op-25). Red circles denote methylated CpG dinucleotides, and yellow circles denote unmethylated CpG dinucleotides. The positions of Op-1 to Op-25 sites with respect to the previously defined centromeric chromatin domains (shaded area) are indicated (refer to Figure 2E for details). Sites showing differential hypermethylation following neocentromere formation are labeled on top. Sites showing differential hypomethylation are denoted by asterisks. CpG dinucleotides that are putative MeCP2-binding sites are indicated by solid diamonds. Upon treatment with 5-aza-dC, a number of CpG orphans (Op-4, Op-9, Op-11, Op-12, Op-17, and Op-18) demonstrated a significant decrease in DNA methylation.