Table 1.

Comparison of studies with available data for < 13 mL/kg/hr of delivered CRRT dose-intensity

	Okamoto et al. [2]	Faria and Libório [3]	Tran et al. [7]
Setting	• Retrospective study • Single center • Japan	• MIMIC IV database • USA	• MIMIC-IV database • USA
N	494	1329	2265
Prescribed dose (mL/kg/hr)	< 13.2 (median 11.8) vs. ≥13.2 (median 16.4)	-	-
Delivered dose (mL/kg/hr)	• 11.3 vs. 16.2	• < 20 vs. ≥20 • < 13 vs. ≥13	• Low (< 20) • Moderate (20–25) • High (> 25) • Subgroup analysis: Very low (< 15) vs. other groups
Definition of dose	Whole-course mean delivered dose	• Traditional Cox model: whole-course mean delivered dose • Marginal structural model: targeting dose-intensity as as-treated time-varying exposure with weights accumulated over 3-day blocks	Whole-course mean delivered dose
Estimates	Multivariable Cox regression model: Adjusted HR 1.73 (95% CI 1.19–2.51)	• Multivariable Cox regression model: Adjusted HR 1.70 (95% CI 1.16–2.49) • MSM adjusted for variables collected every 3 days during CRRT: marginal structural HR 0.87 (95% CI 0.66–1.14)	Multivariable Cox regression model: Adjusted HR 1.74 (95% CI 1.17–2.59) (< 15 mL/kg/h vs. 15-19.9 mL/kg/h group as the reference)