Table 2.
Hazard ratios (95% CIs) of mortality in relation to serum P. gingivalis IgG
| Serum Porphyromonas gingivalis IgG | |||||
|---|---|---|---|---|---|
| < 69 EU | 69–119 EU | > 119 EU | P for trend | 69 + EU | |
| All-cause mortality | |||||
| Cases/person-years | 681/43,037 | 1238/73,783 | 727/36,267 | 1965/110,050 | |
| Age and gender-adjusted HR (95% CI) | 1.00 (ref) | 1.15 (1.10–1.20) | 1.15 (1.05–1.26) | 0.002 | 1.15 (1.09–1.21) |
| Multivariable-adjusted HR (95% CI)* | 1.00 (ref) | 1.10 (1.04–1.16) | 1.11 (1.05–1.17) | < 0.001 | 1.10 (1.05–1.16) |
| CVD mortality | |||||
| Mortality/person-years | 200/36,132 | 350/61,714 | 211/28,845 | 561/90,558 | |
| Age and gender-adjusted HR (95% CI) | 1.00 (ref) | 1.25 (1.10–1.43) | 1.15 (1.01–1.32) | 0.02 | 1.23 (1.08–1.39) |
| Multivariable-adjusted HR (95% CI)* | 1.00 (ref) | 1.23 (1.08–1.39) | 1.22 (1.03–1.44) | 0.010 | 1.23 (1.09–1.38) |
| Cancer mortality | |||||
| Mortality/person-years | 134/35,640 | 256/60,893 | 163/28,446 | 419/89,339 | |
| Age and gender-adjusted HR (95% CI) | 1.00 (ref) | 1.03 (0.96–1.10) | 1.15 (0.99–1.35) | 0.07 | 1.06 (0.99–1.14) |
| Multivariable-adjusted HR (95% CI)* | 1.00 (ref) | 1.06 (0.91–1.23) | 1.22 (1.09–1.37) | 0.007 | 1.10 (0.97–1.25) |
| CeVD mortality | |||||
| Mortality/person-years | 48/34,474 | 58/58,116 | 26/26,639 | 84/84,755 | |
| Age and gender-adjusted HR (95% CI) | 1.00 (ref) | 1.22 (1.07–1.40) | 1.20 (0.98–1.47) | 0.047 | 1.22 (1.05–1.42) |
| Multivariable-adjusted HR (95% CI)* | 1.00 (ref) | 1.31 (1.13–1.53) | 1.25 (1.04–1.49) | 0.01 | 1.30 (1.11–1.51) |
| DM mortality | |||||
| Mortality/person-years | 16/33,946 | 60/58,191 | 35/26,764 | 95/84,955 | |
| Age and gender-adjusted HR (95% CI) | 1.00 (ref) | 2.55 (2.38–2.74) | 2.30 (1.97–2.69) | < 0.001 | 2.49 (2.30–2.69) |
| Multivariable-adjusted HR (95% CI)* | 1.00 (ref) | 2.81 (2.54–3.12) | 2.18 (1.85–2.58) | < 0.001 | 2.66 (2.40–2.96) |
Abbreviations: HR hazard ratio, CI confidence interval, CVD cardiovascular disease, CeVD cerebrovascular disease, DM diabetes mellitus
*The cox proportional hazard models were adjusted by sex (males or females), age (20–39,40–59, ≥ 60 years), race-ethnicity (non-Hispanic white, non-Hispanic black, Mexican American and other), education (less than junior high school, junior high school, high school, college or above), income (< $20,000, ≥ $20,000), smoking status (current smokers, former smokers, never smokers), drinking status (≥ 12 drinks in the past 12 months, < 12 drinks in the past 12 months), exercise (more active, less active, about the same), body mass index (< 18.5, 18.5–24.9, 25–29.9, ≥ 30 kg/m2)