Table 2.
Summary of results of the meta-analysis, with Risk Ratios, heterogeneity and quality of evidence using the GRADE approach
| Outcome measure | No. of participants (arms) | RR (95% CI) | Heterogeneity I2 (%) | GRADE |
|---|---|---|---|---|
| Major limb events | 418,752 (13) | 0.73 (0.65, 0.82) | 81 | ⊕⊕OOa,b Low |
| LEA | 318,579 (9) | 0.76 (0.66, 0.87) | 83 | ⊕⊕OOa,b Low |
| Revascularization | 238,526 (5) | 0.81 (0.77, 0.86) | 0.0 | ⊕⊕⊕Oa Moderate |
| Gangrene | 237,734 (4) | 0.80 (0.77, 0.85) | 0.0 | ⊕⊕⊕Oa Moderate |
| MACE | 121,903 (4) | 0.76 (0.63, 0.90) | 97 | ⊕⊕OOa,b Low |
| All-cause mortality | 305,527 (7) | 0.67 (0.61, 0.73) | 92 | ⊕⊕OOa,b Low |
aEvidence certainty was downgraded one level due to risk of bias
bEvidence certainty was downgraded one level due to inconsistency (heterogeneity in point estimates with I2 up to 75%)