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. 2006 Feb 14;4(3):e52. doi: 10.1371/journal.pbio.0040052

Figure 2. Evolutionary Scenarios for Human-Specific Pseudogenes and Non–Human-Specific Pseudogenes.

Figure 2

Functional genes and pseudogenes are represented by open and closed circles, respectively. A, A1, A2, and B represent hypothetical gene names.

(A) The human-specific pseudogene has a functional chimpanzee ortholog.

(B) The chimpanzee functional gene is most closely related to another chimpanzee functional gene.

(C) The human pseudogene is most closely related to a functional human gene.

(D) The chimpanzee functional ortholog is most closely related to a human functional gene. We consider (A) and (B) as human-specific pseudogenes.