Table 3. Prevalence rates of thoracic aortic aneurysms by coincidental diseases according to (12) and risk assessment based on data from the Suprareglonal Health Service Research Network (SHRN).
| Coincidental disease | Pts n (%) | With TAA n (%) | Risk with disease % | Risk without disease % | Absolute risk increase | OR [95% Cl] | OR (multivariate) [95% Cl] | p-value |
|---|---|---|---|---|---|---|---|---|
| Age ≥ 18 years; male & female | 394 113 | 160 (0.04) | ||||||
| Aortitis | 1 (0.00) | 0(0) | - | 0.04 | - | - | ||
| Giant cell arteritis | 31 (0.01) | 1 (0.6) | 3.23 | 0.04 | 3.19 | 82.6 [2.01; 503.1] | 4.99 [0.52; 47.5] | n. s. |
| Renal cyst | 293 (0.07) | 13 (8.1) | 4.44 | 0.04 | 4.40 | 124.3 [63.9; 222.6] | 6.46 [3.48; 12.0] | < 0.001 |
| Inguinal hernia | 876 (0.22) | 16 (10) | 1.83 | 0.03 | 1.80 | 50.8 [28.1; 85.8] | 2.85 [1.63; 5.00] | < 0.001 |
| Hypothyroidism | 5 288 (1.34) | 29(18.1) | 0.55 | 0.03 | 0.51 | 16.4 [10.5; 24.6] | 3.85 [2.50; 5.92] | < 0.001 |
| Abdominal aortic aneurysm | 87 (0.02) | 14 (8.8) | 16.09 | 0.04 | 16.05 | 517.4 [263.2; 949.8] | 25.6 [13.9; 47.2] | < 0.001 |
| Intracranial aneurysm | 15 (0.00) | 0(0) | - | 0.04 | - | - | ||
| Bicuspid aortic valve | 16 (0.00) | 2(1–3) | 12.50 | 0.04 | 12.46 | 356.2 [38.9; 1569.5] | 43.96 [9.84; 196.5] | < 0.001 |
| Age ≥ 50 years; female | 125 455 | 50 (0.04) | ||||||
| Aortitis | 1 (0.00) | 0(0) | - | 0.04 | - | - | ||
| Giant cell arteritis | 22 (0.02) | 0(0) | - | 0.04 | - | - | ||
| Renal cyst | 113(0.09) | 3(6) | 2.65 | 0.04 | 2.62 | 72.7 [14.3; 231.2] | 4.79 [1.45; 15.8] | < 0.05 |
| Inguinal hernia | 87 (0.07) | 1 (2) | 1.15 | 0.04 | 1.11 | 29.7 [0.70; 178.0] | 2.07 [0.28; 15.3] | n. s. |
| Hypothyroidism | 2718(2.17) | 19 (38) | 0.70 | 0.03 | 0.67 | 27.9 [14.9; 51.0] | 6.39 [3.56; 11.5] | < 0.001 |
| Abdominal aortic aneurysm | 19 (0.02) | 2(4) | 10.53 | 0.04 | 10.49 | 307.3 [33.5; 1350.1] | 24.2 [5.61; 104.2] | < 0.001 |
| Intracranial aneurysm | 6(0.00) | 0(0) | - | 0.04 | - | - | ||
| Bicuspid aortic valve | 1 (0.00) | 0(0) | - | 0.04 | - | - | ||
| Age ≥ 50 years; male | 102 597 | 100 (0.10) | ||||||
| Aortitis | 0(0) | 0(0) | - | 0.10 | - | - | - | |
| Giant cell arteritis | 9(0.01) | 1 (1) | 11.11 | 0.10 | 11.01 | 129.4 [2.89; 979.4] | 25.3 [3.10; 206.3] | < 0.01 |
| Renal cyst | 145 (0.14) | 9(9) | 6.21 | 0.09 | 6.12 | 74.4 [32.3; 151.6] | 6.77 [3.19; 14.4] | < 0.001 |
| Inguinal hernia | 593 (0.58) | 14 (14) | 2.36 | 0.08 | 2.28 | 28.7 [14.9; 51.1] | 2.87 [1.55; 5.30] | < 0.001 |
| Hypothyroidism | 682 (0.66) | 9(9) | 1.32 | 0.09 | 1.23 | 15.0 [6.60; 29.8] | 2.01 [0.96; 4.22] | n. s. |
| Abdominal aortic aneurysm | 66 (0.06) | 12 (12) | 18.18 | 0.09 | 18.10 | 258.7 [121.4; 510.1] | 31.1 [15.9; 60.7] | < 0.001 |
| Intracranial aneurysm | 6(0.01) | 0(0) | - | 0.10 | - | - | - | |
| Bicuspid aortic valve | 7(0.01) | 2(2) | 28.57 | 0.10 | 28.48 | 418.3 [39.3; 2585.0] | 91.8 [18.7; 450.0] | < 0.001 |
The data shown here are derived from a multivariate regression model in which age and sex were included as covariates. Cl, confidence interval; n. s., not significant; OR, odds ratio; Pts, patients; TAA, thoracic aortic aneurysm