. Author manuscript; available in PMC: 2026 Sep 29.

Published in final edited form as: J Control Release. 2023 Oct 31;364:216–226. doi: 10.1016/j.jconrel.2023.10.020

Table 2.

Amount of insulin or 2 k PEGylated insulin loaded before acidifying sample (pre collapse) and after acidifying sample (collapsed). All polymers aside from the PMAA sample were composed of P(MAA-g-EG). The graft length of each polymer is represented by g.

	Graft Length	g: 1000 Da	g: 1000 Da	g: 2000 Da

Sample	MAA	1:1 MAA:EG	3:1 MAA:EG	3:1 MAA:EG

Pre-Collapse
Insulin	6.93 ± 1.79^**	89.16 ± 5.25	61.43 ± 18.29^*	65.89 ± 6.92^*
2 k PEGylated Insulin	76.76 ± 13.83^ΔΔ	28.04 ± 55.95^*	81.75 ± 17.54^Δ	54.58 + 42.38^ΔΔ
Post-Collapse
Insulin	21.04 ± 2.27^**	82.36 ± 2.73	50.59 ± 5.82^*	53.53 ± 3.89^**
2 k PEGylated Insulin	99.73 ± 1.46^**,^ΔΔ	61.24 ± 23.39	96.01 ± 5.58^**,^Δ	100.74 ± 4.55^**,^ΔΔ

Data: mean ± S.D. (n = 3–6)

p < .05

^**

p < .01 when compared to loading results for insulin loading in 1:1 MAA:EG.

^Δ

p < .05

^ΔΔ

p < .01 when 2KPI loaded samples are compared to 2KPI loaded in 1:1 MAA:EG.