Table 3.
Univariate analysis comparing HT versus non-HT groups.
| Variable | HT (n = 28) | Non-HT (n = 153) | Test | Statistic | P value |
|---|---|---|---|---|---|
| Demographic/clinical variables | |||||
| Age, yr | 73.2 ± 8.2 | 66.8 ± 8.7 | Welch t | t = 3.76 | <.001 |
| Sex, male, n (%) | 12 (42.9) | 98 (64.1) | χ2 | χ2 = 4.46 | .035 |
| Baseline NIHSS score | 14.0 ± 4.5 | 9.0 ± 4.0 | Welch t | t = 5.50 | <.001 |
| Onset-to-needle time, min | 149.0 ± 35.6 | 141.0 ± 37.3 | Welch t | t = 1.07 | .285 |
| Baseline SBP, mm Hg | 171.0 ± 18.3 | 162.0 ± 16.5 | Welch t | t = 2.43 | .020 |
| Baseline DBP, mm Hg | 96.0 ± 12.0 | 92.0 ± 11.0 | Welch t | t = 1.64 | .109 |
| Atrial fibrillation, n (%) | 16 (57.1) | 37 (24.2) | χ2 | χ2 = 12.42 | <.001 |
| Hypertension, n (%) | 21 (75.0) | 101 (66.0) | χ2 | χ2 = 0.87 | .351 |
| Diabetes mellitus, n (%) | 10 (35.7) | 41 (26.8) | χ2 | χ2 = 0.74 | .390 |
| Pre-stroke antiplatelet use, n (%) | 12 (42.9) | 34 (22.2) | χ2 | χ2 = 5.32 | .021 |
| Imaging variable | |||||
| ASPECTS score | 7.3 ± 1.0 | 8.1 ± 1.2 | Welch t | t = –3.61 | <.001 |
| Laboratory variables (8 selected indicators) | |||||
| WBC, ×109/L | 9.8 ± 2.7 | 8.4 ± 2.3 | Welch t | t = 2.71 | .009 |
| Neutrophils, ×109/L | 7.1 ± 2.4 | 5.8 ± 2.0 | Welch t | t = 2.98 | .004 |
| Lymphocytes, ×109/L | 1.3 ± 0.5 | 1.7 ± 0.6 | Welch t | t = –3.23 | .002 |
| Hemoglobin, g/L | 128 ± 14 | 135 ± 13 | Welch t | t = –2.59 | .012 |
| Platelets, ×109/L | 224 ± 53 | 234 ± 51 | Welch t | t = –0.95 | .345 |
| INR | 1.10 ± 0.12 | 1.05 ± 0.10 | Welch t | t = 2.25 | .027 |
| Fibrinogen, g/L | 3.1 ± 0.8 | 3.4 ± 0.9 | Welch t | t = –1.93 | .058 |
| D-dimer, mg/L FEU | 1.8 ± 1.0 | 1.1 ± 0.8 | Welch t | t = 3.64 | <.001 |
ASPECTS = Alberta Stroke Program Early CT Score, DBP = diastolic blood pressure, FEU = fibrinogen-equivalent units, HT = hemorrhagic transformation, INR = international normalized ratio, NIHSS = National Institutes of Health Stroke Scale, SBP = systolic blood pressure, WBC = white blood cell count.