Table 1.
Comparison of baseline demographic and clinical characteristics from different hospitals in one-year follow-up.
| Variable | Total | Zhong Shan Hospital of Xiamen | Ji Nan University | χ2 /Z | P |
|---|---|---|---|---|---|
| (N =370) | (N = 320) | (N = 50) | |||
| Sex, n (%) | |||||
| Male | 268 (72.4) | 228 (71.3) | 40 (80.0) | 1.658a | 0.198 |
| Female | 102 (27.6) | 92 (28.7) | 10 (20.0) | ||
| Age, (Years) | 28.0 (22.0, 35.2) | 28.0 (22.0, 35.0) | 29.5 (20.0, 36.5) | -0.060b | 0.952 |
| Course of diagnosis, (Months) | 0.0 (0.0, 9.0) | 0.0 (0.0, 12.0) | 0.0 (0.0, 1.0) | -3.211b | 0.001* |
| Symptoms to diagnosis, (Months) | 6.0 (0.5, 24.0) | 6.0 (0.0, 24.0) | 6.0 (2.8, 17.0) | -1.262b | 0.207 |
| Duration, (Years) | 12.0 (4.0, 45.0) | 13.0 (5.0, 48.0) | 8.5 (3.0, 17.0) | -2.913b | 0.004* |
| Age of onset, (Years) | 26.0 (20.0, 33.0) | 26.0 (20.0, 33.0) | 28.5 (18.0, 35.2) | -0.409b | 0.683 |
| BMI, (kg/m2) | 19.0 (17.3, 21.5) | 19.0 (17.3, 21.5) | 18.6 (17.2, 21.6) | -0.252b | 0.801 |
| Smoking history, n (%) | |||||
| No | 323 (87.3) | 279 (87.2) | 44 (88.0) | 0.026a | 0.873 |
| Yes | 47 (12.7) | 41 (12.8) | 6 (12.0) | ||
| Alcohol consumption history, n (%) | |||||
| No | 340 (91.9) | 293 (91.6) | 47 (94.0) | 0.095a | 0.758 |
| Yes | 30 (8.1) | 27 (8.4) | 3 (6.0) | ||
| Hepatitis B, n (%) | |||||
| No | 333 (90.0) | 286 (89.4) | 47 (94.0) | 1.028a | 0.311 |
| Yes | 37 (10.0) | 34 (10.6) | 3 (6.0) | ||
| Abdominal_history, n (%) | |||||
| No | 192 (51.9) | 157 (49.1) | 35 (70.0) | 7.594a | 0.006* |
| Yes | 178 (48.1) | 163 (50.9) | 15 (30.0) | ||
| Disease behavior, n (%) | |||||
| No-stricturing & No-penetrating | 113 (30.5) | 90 (28.1) | 23 (46.0) | 9.151a | 0.010* |
| Stricturing | 173 (46.8) | 159 (49.7) | 14 (28.0) | ||
| penetrating | 84 (22.7) | 71 (22.2) | 13 (26.0) | ||
| Lesion location, n (%) | |||||
| L1 | 55 (14.9) | 45 (14.1) | 10 (20) | 21.539a | <0.001* |
| L2 | 47 (12.7) | 44 (13.8) | 3 (6) | ||
| L3 | 137 (37) | 106 (33.1) | 31 (62) | ||
| L4 | 7 (1.9) | 7 (2.2) | 0 (0) | ||
| Merge | 124 (33.5) | 118 (36.9) | 6 (12) | ||
| Diarrhea, n (%) | |||||
| No | 103 (27.8) | 91 (28.4) | 12 (24.0) | 0.424a | 0.515 |
| Yes | 267 (72.2) | 229 (71.6) | 38 (76.0) | ||
| Abdominal pain, n (%) | |||||
| No | 57 (15.4) | 53 (16.6) | 4 (8.0) | 2.433a | 0.119 |
| Yes | 313 (84.6) | 267 (83.4) | 46 (92.0) | ||
| Abdominal bloating, n (%) | |||||
| No | 282 (76.2) | 252 (78.8) | 30 (60.0) | 8.387a | 0.004* |
| Yes | 88 (23.8) | 68 (21.3) | 20 (40.0) | ||
| Gastrointestinal bleeding, n (%) | |||||
| No | 255 (68.9) | 233 (72.8) | 22 (44.0) | 16.759a | <0.001* |
| Yes | 115 (31.1) | 87 (27.2) | 28 (56.0) | ||
| Weight loss, n (%) | |||||
| No | 218 (58.9) | 184 (57.5) | 34 (68.0) | 1.970a | 0.160 |
| Yes | 152 (41.1) | 136 (42.5) | 16 (32.0) | ||
| Vomiting, n (%) | |||||
| No | 321 (86.8) | 277 (86.6) | 44 (88.0) | 0.078a | 0.780 |
| Yes | 49 (13.2) | 43 (13.4) | 6 (12.0) | ||
| Nausea, n (%) | |||||
| No | 312 (84.3) | 270 (84.4) | 42 (84.0) | 0.005a | 0.946 |
| Yes | 58 (15.7) | 50 (15.6) | 8 (16.0) | ||
| Fever, n (%) | |||||
| No | 302 (81.6) | 261 (81.6) | 41 (82.0) | 0.006a | 0.941 |
| Yes | 68 (18.4) | 59 (18.4) | 9 (18.0) | ||
| Anemia, n (%) | |||||
| None | 160 (43.2) | 137 (42.8) | 23 (46.0) | -0.244b | 0.807 |
| Mild | 155 (41.9) | 139 (43.4) | 16 (32.0) | ||
| Moderate | 50 (13.5) | 40 (12.5) | 10 (20.0) | ||
| Severe | 5 (1.4) | 4 (1.3) | 1 (2.0) | ||
| Poor appetite, n (%) | |||||
| No | 273 (73.8) | 237 (74.1) | 36 (72.0) | 0.095a | 0.758 |
| Yes | 97 (26.2) | 83 (25.9) | 14 (28.0) | ||
| Fatigue, n (%) | |||||
| No | 303 (81.9) | 259 (80.9) | 44 (88.0) | 1.455a | 0.228 |
| Yes | 67 (18.1) | 61 (19.1) | 6 (12.0) | ||
| Another organ complication history, n (%) | |||||
| No | 327 (88.4) | 281 (87.8) | 46 (92.0) | 0.738a | 0.390 |
| Yes | 43 (11.6) | 39 (12.2) | 4 (8.0) | ||
| Abdominal complication history, n (%) | |||||
| No | 308 (83.2) | 268 (83.8) | 40 (80.0) | 0.436a | 0.509 |
| Yes | 62 (16.8) | 52 (16.3) | 10 (20.0) | ||
| Anal complication history, n (%) | |||||
| No | 162 (43.8) | 123 (38.4) | 39 (78.0) | 27.499a | <0.001* |
| Yes | 208 (43.8) | 197 (61.6) | 11 (22.0) | ||
| Frequency of Loose Stools | 10.0 (0.0, 21.0) | 10.0 (0.0, 20.0) | 14.0 (7.0, 21.0) | -2.727b | 0.006* |
| Abdominal Pain Severity (0-3) | 7.0 (2.0, 14.0) | 10.0 (7.0, 14.0) | 1.0 (1.0, 2.0) | -7.388b | <0.001* |
| General Condition (0-4) | 14.0 (7.0, 17.0) | 14.0 (11.0, 18.0) | 2.0 (1.0, 2.0) | -11.415b | <0.001* |
| Extramural complications, n (%) | |||||
| 0 | 155 (41.9) | 111 (34.7) | 44 (88.0) | -6.714a | <0.001* |
| 1 | 130 (35.1) | 125 (39.1) | 5 (10.0) | ||
| 2 | 72 (19.5) | 71 (22.2) | 1 (2.0) | ||
| 3 | 11 (3.0) | 11 (3.4) | 0 (0.0) | ||
| 4 | 2 (0.5) | 2 (0.6) | 0 (0.0) | ||
| Opioid antidiarrheal medications, n (%) | |||||
| No | 369 (99.7) | 320 (100.0) | 49 (98.0) | 1.142a | 0.135 |
| Yes | 1 (0.3) | 0 (0.0) | 1 (2.0) | ||
| Reduced Hematocrit | 2.0 (0.0, 5.9) | 2.1 (0.0, 5.7) | 1.9 (-2.6, 7.5) | -0.605b | 0.546 |
| (Standard - Actual) / Standard Weight | 13.0 (2.9, 22.2) | 12.7 (3.1, 22.3) | 14.1 (1.6, 22.0) | -0.131b | 0.896 |
| CDAI Score | 222.8 (153.3, 260.2) | 229.8 (179.3, 267.2) | 79.0 (51.0, 110.5) | -9.602b | <0.001* |
| Activity, n (%) | |||||
| Remission | 87 (23.5) | 43 (13.4) | 44 (88.0) | 133.677a | <0.001* |
| Active | 283 (76.5) | 277 (86.6) | 6 (12.0) | ||
| WBC (×10^9) | 6.6 (5.2, 8.7) | 6.5 (5.1, 8.5) | 8.1 (5.7, 10.4) | -2.650b | 0.008* |
| RBC (×10^12) | 4.5 (4.0, 5.0) | 4.5 (4.0, 5.0) | 4.7 (4.2, 5.0) | -1.733b | 0.083 |
| HB (g/L) | 117.5 (102.0, 133) | 117.5 (102.0, 132.0) | 118.5 (98.5, 135.0) | -0.065b | 0.948 |
| MCV (fL) | 83.9 (78.0, 88.0) | 84.2 (78.9, 88.0) | 81.7 (72.9, 88.1) | -1.801b | 0.072 |
| MCH (Pg) | 26.9 (24.2, 28.5) | 27.0 (24.3, 28.6) | 25.9 (22.6, 28.4) | -1.957b | 0.050* |
| MCHC (g/L) | 318.4 (307.0, 329.0) | 319.0 (307.0, 329.0) | 315.3 (308.5, 324.8) | -0.725b | 0.469 |
| HCT (%) | 36.9 (32.8, 40.9) | 36.9 (33.2, 40.7) | 37.5 (31.7, 42.6) | -0.218b | 0.827 |
| PLT (×10^9) | 325.5 (256.8, 404.0) | 325.5 (258.0, 403.8) | 328.9 (250.3, 409.9) | -0.143b | 0.886 |
| ESR (mm/h) | 26.6 (15.8, 47.7) | 26.3 (15.0, 46.5) | 40.0 (21.8, 56.2) | -2.181b | 0.029* |
| CRP (mg/L) | 17.1 (5.0, 51.1) | 17.0 (5.0, 45.7) | 26.2 (5.6, 65.2) | -1.349b | 0.177 |
| TP (g/L) | 69.7 (63.2, 75.1) | 70.2 (63.9, 75.2) | 68.2 (61.4, 72.6) | -2.042b | 0.041* |
| ALB (g/L) | 37.0 (32.9, 40.6) | 37.0 (32.9, 40.6) | 37.0 (32.4, 40.7) | -0.092b | 0.926 |
| Urea Nitrogen (mmol/L) | 3.7 (3.0, 4.6) | 3.7 (3.0, 4.6) | 3.8 (3.0, 5.0) | -0.863b | 0.388 |
| Serum Potassium (mmol/L) | 3.9 (3.6, 4.2) | 3.9 (3.6, 4.1) | 4.1 (3.7, 4.3) | -2.918b | 0.004* |
| Uric Acid (μmol/L) | 333.8 (266.5, 393.5) | 330.1 (262.0, 390.0) | 354.6 (307.5, 411.6) | -1.879b | 0.060 |
| HDL (mmol/L) | 1.0 (0.8, 1.1) | 1.0 (0.8, 1.1) | 1.0 (0.7, 1.3) | -0.467b | 0.640 |
| Cholesterol (mmol/L) | 3.5 (3.0, 4.1) | 3.5 (3.0, 4.1) | 3.9 (3.2, 4.5) | -2.624b | 0.009* |
| Triglycerides (mmol/L) | 0.9 (0.7, 1.2) | 0.9 (0.7, 1.2) | 0.9 (0.8, 1.1) | -0.702b | 0.482 |
| Folic Acid (nmol/L) | 11.5 (7.6, 16.2) | 12.1 (7.9, 16.7) | 9.5 (7.3, 11.9) | -2.879b | 0.004* |
| VitB12 (pmmol/L) | 310.7 (260.7, 384.8) | 299.0 (251.2, 379.2) | 375.3 (327.5, 412.3) | -4.462b | <0.001* |
| Fe (umol/L) | 8.4 (5.2, 11.8) | 8.8 (5.1, 11.8) | 7.5 (5.4, 11.4) | -0.400b | 0.689 |
| Total Iron-Binding Capacity (umol/L) | 48.9 (42.0,54.4) | 48.0 (41.2,54.1) | 52.9 (47.2,57.2) | -3.512b | <0.001* |
| Serum Ferritin (ng/mL) | 128.0 (66.5, 205.1) | 122.4 (63.0, 202.8) | 156.6 (119.5, 219.5) | -2.446b | 0.014* |
| Serum Transferrin (g/L) | 2.0 (1.8, 2.2) | 2.0 (1.8, 2.2) | 2.0 (1.7, 2.1) | -1.089b | 0.276 |
| Soluble Transferrin Receptor (mg/L) | 1.3 (1.1, 1.6) | 1.2 (1.1, 1.5) | 31.7 (1.8, 31.8) | -8.734b | <0.001* |
| Fecal occult blood, n (%) | |||||
| No | 74 (20.0) | 57 (17.8) | 17 (34.0) | 7.082a | 0.008* |
| Yes | 296 (80.0) | 263 (82.2) | 33 (66.0) | ||
| Calprotectin, n (%) | |||||
| No | 11 (3.0) | 11 (3.4) | 0 (0.0) | 0.780a | 0.377 |
| Yes | 359 (97.0) | 309 (96.6) | 50 (100.0) | ||
| Fibrinogen (mg/L) | 4.0 (3.2, 4.7) | 3.9 (3.2, 4.7) | 4.3 (3.3, 5.3) | -1.644b | 0.100 |
| D-Dimer(mg/L) | 0.3 (0.2, 0.6) | 0.3 (0.2, 0.6) | 0.4 (0.2, 0.8) | -2.486b | 0.013* |
| Total enteral nutrition, n (%) | |||||
| No | 268 (72.4) | 230 (71.9) | 38 (76.0) | 0.368a | 0.544 |
| Yes | 102 (27.6) | 90 (28.1) | 12 (24.0) | ||
Continuous data exhibiting a non-normal distribution are summarized as medians (IQR), while categorical variables are presented as frequencies and percentages.
*p < 0.05. a: Calculated via Chi-square test. b: Calculated via Mann-Whitney U test.