Table 1.
Top 10 upregulated and downregulated genes in 1A. HCA–Normoxia compared with No HCA–Normoxia (control), 1B. No HCA–Hyperoxia compared with No HCA–Normoxia (control) and 1C. HCA–Hyperoxia compared with No HCA–Normoxia (control).
| Upregulated genes | Downregulated genes | ||||||
|---|---|---|---|---|---|---|---|
| Probe ID | Genes | Fold change | p-Value | Probe ID | Genes | Fold change | p-Value |
| 1A. HCA–Normoxia compared with No HCA–Normoxia (control) | |||||||
| TC0700012849.hg.1 | CLEC5A | 32.34 | 0.0055 | TC0200016484.hg.1 | RGPD2; RGPD1 | −7.26 | 0.0089 |
| TC0200015650.hg.1 | FN1 | 22.64 | 0.0058 | TC0600011499.hg.1 | HLA-DQB1 | −5.43 | 0.0429 |
| TC0100009560.hg.1 | CD101 | 10.18 | 0.0002 | TC0900011613.hg.1 | FAM102A | −4.12 | 0.0483 |
| TC0100016185.hg.1 | FCGR3A | 8.31 | 0.001 | TC0500007138.hg.1 | IL7R | −3.92 | 0.0473 |
| TC0100016189.hg.1 | FCGR3B | 7.81 | 0.0065 | TC0200016511.hg.1 | IL1RN | −3.75 | 0.0015 |
| TC0100018310.hg.1 | FCGR2B | 7.75 | 0.0003 | TC0600007868.hg.1 | RNF8 | −3.15 | 0.0007 |
| TC0500008632.hg.1 | SLC22A5 | 6.72 | 0.0048 | TC1600006445.hg.1 | HBA2 | −3.1 | 0.0312 |
| TC1500006925.hg.1 | THBS1 | 6.33 | 0.0078 | TC1600006446.hg.1 | HBA1 | −3.07 | 0.0433 |
| TC1900009546.hg.1 | PRAM1 | 6.22 | 0.0058 | TC1200007209.hg.1 | DDX11 | −3.04 | 0.0009 |
| TC0400012947.hg.1 | GPRIN3 | 5.89 | 0.0003 | TC0600011173.hg.1 | GUSBP2 | −2.95 | 0.0093 |
| 1B. No HCA–Hyperoxia compared with No HCA–Normoxia (control) | |||||||
| TC0200016648.hg.1 | CDC42EP3 | 4.79 | 0.0106 | TC0100014857.hg.1 | GBP5 | −7.25 | 0.0295 |
| TC0800010607.hg.1 | ASPH | 4.45 | 0.0037 | TC0X00006626.hg.1 | TLR8 | −6.68 | 0.0164 |
| TC1900009824.hg.1 | DNAJB1 | 3.81 | 0.0013 | TC1700011442.hg.1 | PECAM1 | −6.52 | 0.0089 |
| TC0300014095.hg.1 | TM4SF19 | 3.48 | 0.0031 | TC0300013146.hg.1 | TNFSF10 | −6.37 | 0.0426 |
| TC0400007836.hg.1 | CXCL8 | 2.96 | 0.0033 | TC1700012440.hg.1 | RNFT1 | −4.93 | 0.0104 |
| TC0300014092.hg.1 | TM4SF19-TCTEX1D2 | 2.85 | 0.0009 | TC0700011584.hg.1 | FGL2 | −4.83 | 0.0371 |
| TC0100014313.hg.1 | PPAP2B | 2.84 | 0.0308 | TC1200010618.hg.1 | TUBA1A | −4.59 | 0.0456 |
| TC0100018443.hg.1 | PLPP3 | 2.8 | 0.026 | TC1900008669.hg.1 | FPR3 | −4.48 | 0.0455 |
| TC1100010054.hg.1 | NRIP3 | 2.69 | 0.0489 | TC0400012922.hg.1 | TLR6 | −4.39 | 0.0428 |
| TC0500008054.hg.1 | POLR3G | 2.69 | 0.0085 | TC0300010358.hg.1 | XPC | −4.33 | 0.0063 |
| 1C. HCA–Hyperoxia compared with No HCA–Normoxia (control) | |||||||
| TC0700012849.hg.1 | CLEC5A | 79.2 | 8.53E−05 | TC0700013047.hg.1 | TMEM176B | −20.54 | 0.0476 |
| TC0200015650.hg.1 | FN1 | 28.26 | 0.0082 | TC1000008400.hg.1 | IFIT1 | −10.59 | 0.0264 |
| TC2100008027.hg.1 | KCNE1 | 11.65 | 0.0133 | TC2200006540.hg.1 | USP18 | −9.31 | 0.0196 |
| TC0500013301.hg.1 | DAB2 | 10.15 | 0.0075 | TC1000008396.hg.1 | IFIT2 | −6.27 | 0.0238 |
| TC1300006979.hg.1 | RGCC | 9.78 | 1.93E−05 | TC0100010874.hg.1 | RGL1 | −6.11 | 0.0095 |
| TC0400012947.hg.1 | GPRIN3 | 9.33 | 3.66E−05 | TC0200012652.hg.1 | PNPT1 | −5.61 | 0.0365 |
| TC0800008299.hg.1 | SDC2 | 8.96 | 0.0008 | TC0600011499.hg.1 | HLA-DQB1 | −5.51 | 0.0369 |
| TC0700011561.hg.1 | CCL24 | 8.94 | 0.0408 | TC0200016484.hg.1 | RGPD2; RGPD1 | −5.24 | 0.0088 |
| TC0600009381.hg.1 | CENPW | 8.86 | 0.0001 | TC1200008920.hg.1 | OAS3 | −4.49 | 0.0431 |
| TC0500007895.hg.1 | CMYA5 | 8.57 | 0.0058 | TC0300013146.hg.1 | TNFSF10 | −4.26 | 0.0412 |