Table 4.

Top upstream regulators from ingenuity pathway analysis.

Group comparison	Upstream regulator	Molecule type	Predicted activation state	Activation z-score	p-Value of overlap
HCA–Normoxia versus No HCA–Normoxia (control)	IFNG	Cytokine	Activated	2.73	8.57E−21
	dexamethasone	Chemical drug	Activated	2.161	7.13E−18
	IMMUNOGLOBULIN (complex)	Complex	Inhibited	−2.315	1.12E−16
	lipopolysaccharide	Chemical drug	Activated	5.688	3.19E−16
	HNF4A	Transcription regulator		−0.104	1.37E−15
	TNF	Cytokine	Activated	3.909	1.85E−12
	Camptothecin	Chemical drug		1.147	4.94E−12
	CSF1	Cytokine	Activated	2.515	5.01E−12
	TP73	Transcription regulator		1.226	5.11E−12
	TP53	Transcription regulator	Activated	2.026	6.25E−12
No HCA–Hyperoxia versus No HCA–Normoxia (control)	TREM-1	Transmembrane receptor	Activated	2.665	1.54E−11
	FAS	Transmembrane receptor		−0.798	1.22E−07
	dexamethasone	Chemical drug		−1.126	3.61E−06
	GSKJ4	Chemical reagent	Activated	2.538	4.75E−06
	MAP2K4	Kinase		0.104	7.42E−06
	HNF4A	Transcription regulator		−1.373	7.43E−06
	TNFRSF9	Transmembrane receptor		0.249	1.16E−05
	GW9662	Chemical reagent		−0.523	0.000018
	Ascomycin	Chemical reagent			2.23E−05
	Camptothecin	Chemical drug	Activated	2.375	2.31E−05
HCA–Hyperoxia versus No HCA–Normoxia (control)	HNF4A	transcription regulator		−0.327	1.36E−26
	lipopolysaccharide	Chemical drug	Activated	6.114	2.42E−25
	arsenic trioxide	Chemical drug	Activated	2.612	1.08E−24
	TNF	Cytokine	Activated	5.768	4.23E−22
	IFNG	Cytokine	Activated	2.065	4.72E−22
	Dexamethasone	Chemical drug	Activated	2.532	2.85E−21
	beta-estradiol	Chemical—endogenous mammalian	Activated	2.882	2.94E−21
	TGFB1	Growth factor	Activated	3.557	4.11E−21
	LDL (complex)	Complex	Activated	2.765	4.88E−21
	Immunoglobulin (complex)	Complex		−1.068	1.61E−19