Effect of FIV infection on CD4+ (A), CD8+ (B), and CD8α+βlow (C) lymphocyte subsets. The percentage of peripheral blood lymphoid cells expressing CD4 and CD8 was quantified in each of the three study groups, GL8414 infected (○), PETF14 infected (□), or mock infected with PBS (▿), by flow cytometry, and the absolute cell number of each subset was calculated from the results of hematological analysis. Results are expressed as the mean (± standard error) cell number (109/liter); ∗ denotes a statistically significant difference (P = 0.046).