TABLE 1.
Protection against Ebola Zaire virus challengea
| Antibody | Antibody dose (mg/kg) | Time of antibody treatment (h) | Day of death | Plasma viremia (log PFU/ml)b |
|---|---|---|---|---|
| KZ52 | 50 | 0 | — | <1.4 |
| 50 | 0 | — | 1.4 | |
| 50 | 0 | — | 4.5 | |
| 5 | 0 | — | 3.9 | |
| 5 | 0 | — | 3.9 | |
| 5 | 0 | 14 | 5.5 | |
| 0.5 | 0 | 7 | 4.7 | |
| 0.5 | 0 | 8 | 4.3 | |
| 0.5 | 0 | 7 | 5.1 | |
| Human IgG | 50 | 0 | 7 | 4.2 |
| 50 | 0 | 7 | 4.5 | |
| 50 | 0 | 7 | 5.6 | |
| 5 | 0 | 12 | 4.9 | |
| 5 | 0 | 12 | 4.2 | |
| 5 | 0 | 12 | 5.1 | |
| 0.5 | 0 | 9 | 4.8 | |
| 0.5 | 0 | 9 | 4.1 | |
| 0.5 | 0 | 7 | 3.9 | |
| None | n/a | n/a | 9 | 4.1 |
| n/a | n/a | 9 | 4.4 | |
| n/a | n/a | 10 | 2.8 | |
| n/a | n/a | 10 | 2.8 | |
| n/a | n/a | — | 2.6 |
a
Animals were treated with the antibody and dose indicated at the time of challenge. —, animal lived; n/a, not applicable.
b
Plasma viremia was assessed on day 7 postchallenge.