TABLE 2.
Postexposure prophylaxis of Ebola Zaire virus challengea
| Antibody | Antibody doseb | Time of antibody treatment (h) | Day of death | Plasma viremia (log PFU/ml)c |
|---|---|---|---|---|
| KZ52 | 25 | −1 | — | <1.4 |
| 25 | −1 | — | <1.4 | |
| 25 | −1 | — | <1.4 | |
| 25 | −1 | — | <1.4 | |
| 25 | −1 | — | <1.4 | |
| 25 | +1 | — | 2.4 | |
| 25 | +1 | — | 3.5 | |
| 25 | +1 | — | 4.0 | |
| 25 | +1 | — | 3.5 | |
| 25 | +1 | 9 | 6.2 | |
| 25 | +6 | 11 | 4.3 | |
| 25 | +6 | 9 | 2.9 | |
| 25 | +6 | 9 | 4.6 | |
| 25 | +6 | 10 | 4.8 | |
| 25 | +6 | 8 | 5.2 | |
| Equine IgG | 3 | 0 | — | <1.4 |
| 3 | 0 | — | <1.4 | |
| 3 | 0 | — | <1.4 | |
| 3 | 0 | — | <1.4 | |
| 3 | 0 | — | <1.4 | |
| None | n/a | n/a | 10 | 4.1 |
| n/a | n/a | 9 | 4.3 | |
| n/a | n/a | 9 | 5.0 | |
| n/a | n/a | 8 | 4.9 | |
| n/a | n/a | 8 | 4.9 |
a
Animals were administered the antibody at the indicated dose before or after challenge. —, animal lived; n/a, not applicable.
b
KZ52 dose is in milligrams per kilogram of body weight; equine IgG dose is in milliliters per kilogram.
c
Plasma viremia was assessed on day 7 postchallenge.