Table 1.

Resistance of Bid^−/− mice to anti-Fas-induced mortality and hepatocyte injury

Mice	Survival at 48 h (%)	Survival time of deceased animals (h) (mean ± s.d.)	2h (mean ± s.d.)	Histology scores* 2.5–3.5h	6–9 h
WT	12.5%	3.2 ± 1.3	1, 2, 3, 3†	3‡, 3‡	3‡
	(n = 8)	(n = 7	(2.3 ± 1.0)
Bid−/−	81.8%	6.6 ± 1.3	0, 0, 1, 0†	0†,1†	3‡
	(n = 11)	(n = 2)	(0.3 ± 0.5)
P ¶	<0.01	0.01	0.01	-	-

^*Semiquantitative histological scoring of liver injury (see Methods). Data shown are scores for each mouse and also mean ± s.d. for animals killed at the 2-h timepoint.

^†WT and Bid^−/− mice were killed at matched timepoints for comparison.

^‡Animals were killed when they became symptomatic.

^¶Statistics were performed using χ² test for survival rate, t-test for mean survival time and mean histology score.