Table 2.

Longitudinal changes in body weight and nutritional indicators during and after radiotherapy (n = 680).

Variable	Baseline	Mid-radiotherapy	End of radiotherapy	Early follow-up	p-value
Body weight, kg	69.4 ± 14.8	67.9 ± 14.7	65.8 ± 14.6	65.2 ± 14.5	<0.001
Change from baseline, kg	–	−1.5 ± 1.8	−3.6 ± 3.2	−4.2 ± 4.0	<0.001
Percentage weight change	–	−2.2 ± 2.6	−5.2 ± 4.5	−6.0 ± 5.6	<0.001
Clinically significant weight loss, ≥5%	0	59 (8.7)	303 (44.6)	352 (51.8)	<0.001
Critical weight loss	0	21 (3.1)	187 (27.5)	232 (34.1)	<0.001
Serum albumin, g/L	38.1 ± 5.0	36.7 ± 5.2	34.8 ± 5.3	35.2 ± 5.4	<0.001
Hypoalbuminemia, <35 g/L	132 (19.4)	228 (33.5)	313 (46.0)	291 (42.8)	<0.001
PNI	46.7 ± 6.1	44.8 ± 6.3	42.8 ± 6.4	43.2 ± 6.6	<0.001
Low PNI, <45	251 (36.9)	348 (51.2)	413 (60.7)	401 (59.0)	<0.001

Continuous variables are presented as mean ± SD, and categorical variables are presented as n (%). p-values were derived from repeated-measures analyses. PNI, prognostic nutritional index.