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. 2026 Sep 16;16:1891664. doi: 10.3389/fcimb.2026.1891664

Table 5.

DeLong test comparisons of the 7-variable risk model with conventional severity scores for predicting 28-day ICU mortality.

Cohort Comparison Model AUC Score AUC Difference P value
Training Model vs SOFA 0.674 0.632 0.042 0.014
Training Model vs APS III 0.674 0.668 0.006 0.727
Training Model vs SAPS II 0.674 0.673 0.001 0.961
Training Model vs OASIS 0.674 0.594 0.080 <0.001
Training Model vs Charlson 0.674 0.576 0.098 <0.001
Training Model vs APACHE II 0.674 0.635 0.039 0.034
Validation Model vs SOFA 0.677 0.642 0.035 0.208
Validation Model vs APS III 0.677 0.650 0.027 0.319
Validation Model vs SAPS II 0.677 0.665 0.012 0.709
Validation Model vs OASIS 0.677 0.641 0.037 0.309
Validation Model vs Charlson 0.677 0.636 0.042 0.230
Validation Model vs APACHE II 0.677 0.615 0.062 0.041
External Model vs SOFA 0.783 0.687 0.096 0.012
External Model vs APS III 0.783 0.680 0.103 0.018
External Model vs SAPS II 0.783 0.682 0.101 0.032
External Model vs OASIS 0.783 0.763 0.020 0.676
External Model vs Charlson 0.783 0.629 0.154 0.006
External Model vs APACHE II 0.783 0.647 0.135 0.001

AUC , area under the receiver operating characteristic curve. P value from DeLong test for pairwise AUC comparison. Bold P values indicate statistical significance (P < 0.05).