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. 2026 Sep 16;13:1953997. doi: 10.3389/fmed.2026.1953997

Figure 4.

Three-by-two grid of ROC curve graphics compares diagnostic performance for conventional ultrasound, contrast-enhanced ultrasound, and their combination. Cross-validation results are shown in the top row, with AUCs of 0.814, 0.848, and 0.936 respectively. Independent testing results are in the bottom row, with AUCs of 0.820, 0.915, and 0.920. Each ROC curve plots sensitivity versus 1-specificity, demonstrating improved classification accuracy when combining methods.

ROC curves of the three radiomics models: ROC curves compare the conventional ultrasound, CEUS, and combined ultrasound radiomics models in the cross-validation and independent test sets. The default plot titles have been removed. ROC, receiver operating characteristic; AUC, area under the curve; CEUS, contrast-enhanced ultrasound.